Maternal and Neonatal Outcomes of SARS-CoV-2 Infection in a Cohort of Pregnant Women with Comorbid Disorders

被引:11
作者
Benamor Teixeira, Maria de Lourdes [1 ,2 ]
Ferreira Junior, Orlando da Costa [3 ]
Joao, Esau [1 ]
Fuller, Trevon [1 ,2 ]
Esteves, Juliana Silva [1 ,4 ]
Mendes-Silva, Wallace [1 ,4 ,5 ]
Mocarzel, Carolina Carvalho [1 ,4 ]
Maia, Richard Araujo [3 ]
Boullosa, Lidia Theodoro [3 ]
Alves Goncalves, Cassia Cristina [3 ]
Frankel, Patricia Pontes [1 ,4 ]
Fragoso da Silveira Gouvea, Maria Isabel [1 ,2 ]
机构
[1] Hosp Fed Servidores Estado, Infect Dis Dept, Rua Sacadura Cabral 178,Anexo IV 4 Andar, BR-20221161 Rio De Janeiro, RJ, Brazil
[2] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, Av Brasil 4365, BR-21040360 Rio De Janeiro, RJ, Brazil
[3] Univ Fed Rio de Janeiro, Inst Biol, Dept Genet, Lab Biol Mol, Av Carlos Chagas Filho 373,Sala A1-050, BR-21941902 Rio De Janeiro, RJ, Brazil
[4] Hosp Fed Servidores Estado, Maternal Fetal Dept, Rua Sacadura Cabral 178, BR-20221161 Rio De Janeiro, RJ, Brazil
[5] Univ Fed Rio de Janeiro, Perinatal Hlth Program, Maternidade Escola, Av Carlos Chagas Filho 373,Sala A1-050, BR-21941902 Rio De Janeiro, RJ, Brazil
来源
VIRUSES-BASEL | 2021年 / 13卷 / 07期
关键词
SARS-CoV-2; HIV; obesity; obstetrics; pregnancy; SYNDROME CORONAVIRUS 2;
D O I
10.3390/v13071277
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
There are some reports and case series addressing Coronavirus Disease 2019 (COVID-19) infections during pregnancy in upper income countries, but there are few data on pregnant women with comorbid conditions in low and middle income Countries. This study evaluated the proportion and the maternal and neonatal outcomes associated with SARS-CoV-2 infection among pregnant women with comorbidities. Participants were recruited consecutively in order of admission to a maternity for pregnant women with comorbidities. Sociodemographic, clinical, and laboratory data were prospectively collected during hospitalization. Pregnant women were screened at entry: nasopharyngeal swabs were tested by RT-PCR; serum samples were tested for IgG antibodies against spike protein by ELISA. From April to June 2020, 115 eligible women were included in the study. The proportion of SARS-CoV-2 infection was 28.7%. The rate of obesity was 60.9%, vascular hypertension 40.0%, and HIV 21.7%. The most common clinical presentations were ageusia (21.2%), anosmia (18.2%), and fever (18.2%). Prematurity was higher among mothers who had a SARS-CoV-2 infection based on RT-PCR. There were two cases of fetal demise. We found a high proportion of COVID-19 among pregnant women with comorbidities. This underscores the importance of antenatal care during the pandemic to implement universal SARS-CoV-2 screening, precautionary measures, and the rollout of vaccination programs for pregnant women.
引用
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页数:10
相关论文
共 38 条
[1]   Clinical Presentation of Coronavirus Disease 2019 (COVID-19) in Pregnant and Recently Pregnant People [J].
Afshar, Yalda ;
Gaw, Stephanie L. ;
Flaherman, Valerie J. ;
Chambers, Brittany D. ;
Krakow, Deborah ;
Berghella, Vincenzo ;
Shamshirsaz, Alireza A. ;
Boatin, Adeline A. ;
Aldrovandi, Grace ;
Greiner, Andrea ;
Riley, Laura ;
Boscardin, W. John ;
Jamieson, Denise J. ;
Jacoby, Vanessa L. .
OBSTETRICS AND GYNECOLOGY, 2020, 136 (06) :1117-1125
[2]   Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis [J].
Allotey, John ;
Stallings, Elena ;
Bonet, Mercedes ;
Yap, Magnus ;
Chatterjee, Shaunak ;
Kew, Tania ;
Debenham, Luke ;
Llavall, Anna Clave ;
Dixit, Anushka ;
Zhou, Dengyi ;
Balaji, Rishab ;
Lee, Siang Ing ;
Qiu, Xiu ;
Yuan, Mingyang ;
Coomar, Dyuti ;
van Wely, Madelon ;
van Leeuwen, Elizabeth ;
Kostova, Elena ;
Kunst, Heinke ;
Khalil, Asma ;
Tiberi, Simon ;
Brizuela, Vanessa ;
Broutet, Nathalie ;
Kara, Edna ;
Kim, Caron Rahn ;
Thorson, Anna ;
Oladapo, Olufemi T. ;
Mofenson, Lynne ;
Zamora, Javier ;
Thangaratinam, Shakila .
BMJ-BRITISH MEDICAL JOURNAL, 2020, 370
[3]  
American College of Obstetricians and Gynecologists Practice Advisory, 2020, NOV COR 2019 COVID 1
[4]  
[Anonymous], 2020, INT GUID COLL HANDL
[5]   Maternal mortality from COVID 19 among South African pregnant women [J].
Basu, Jayati Kusari ;
Chauke, Lawrence ;
Magoro, Terrance .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2022, 35 (25) :5932-5934
[6]   Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals [J].
Breslin, Noelle ;
Baptiste, Caitlin ;
Gyamfi-Bannerman, Cynthia ;
Miller, Russell ;
Martinez, Rebecca ;
Bernstein, Kyra ;
Ring, Laurence ;
Landau, Ruth ;
Purisch, Stephanie ;
Friedman, Alexander M. ;
Fuchs, Karin ;
Sutton, Desmond ;
Andrikopoulou, Maria ;
Rupley, Devon ;
Sheen, Jean-Ju ;
Aubey, Janice ;
Zork, Noelia ;
Moroz, Leslie ;
Mourad, Mirella ;
Wapner, Ronald ;
Simpson, Lynn L. ;
D'Alton, Mary E. ;
Goffman, Dena .
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM, 2020, 2 (02)
[7]   Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis [J].
Buitrago-Garcia, Diana ;
Egli-Gany, Dianne ;
Counotte, Michel J. ;
Hossmann, Stefanie ;
Imeri, Hira ;
Ipekci, Aziz Mert ;
Salanti, Georgia ;
Low, Nicola .
PLOS MEDICINE, 2020, 17 (09)
[8]   Prevalence of SARS-CoV-2 Among Patients Admitted for Childbirth in Southern Connecticut [J].
Campbell, Katherine H. ;
Tornatore, Jean M. ;
Lawrence, Kirsten E. ;
Illuzzi, Jessica L. ;
Sussman, L. Scott ;
Lipkind, Heather S. ;
Pettker, Christian M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (24) :2520-2522
[9]  
CDC, 2020, INF CONTR GUID HEALT
[10]   Effects of the COVID-19 pandemic on maternal and perinatal outcomes: a systematic review and meta-analysis [J].
Chmielewska, Barbara ;
Barratt, Imogen ;
Townsend, Rosemary ;
Kalafat, Erkan ;
van der Meulen, Jan ;
Gurol-Urganci, Ipek ;
Brien, Pat O. ;
Morris, Edward ;
Draycott, Tim ;
Thangaratinam, Shakila ;
Le Doare, Kirsty ;
Ladhani, Shamez ;
von Dadelszen, Peter ;
Magee, Laura ;
Khalil, Asma .
LANCET GLOBAL HEALTH, 2021, 9 (06) :E759-E772