A comprehensive genetic map of the human genome based on 5,264 microsatellites

被引：2672

作者：

Dib, C

Faure, S

Fizames, C

Samson, D

Drouot, N

Vignal, A

Millasseau, P

Marc, S

Hazan, J

Seboun, E

Lathrop, M

Gyapay, G

Morissette, J

Weissenbach, J

机构：

[1] GENETHON SA,F-91000 EVRY,FRANCE

[2] CNRS,URA 1922,F-91000 EVRY,FRANCE

[3] HOP ST LOUIS,INSERM,U358,PARIS,FRANCE

[4] CHU LAVAL,CTR RECH,QUEBEC CITY,PQ G1V 4G2,CANADA

来源：

NATURE | 1996年 / 380卷 / 6570期

关键词：

D O I：

10.1038/380152a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps(1-6), which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites(7,8). We report here the last version of the Genethon human linkage map(6). This map consists of 5,264 short tandem (AC/TG)(n) repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.

引用

页码：152 / 154

页数：3

共 21 条

[1] A GENETIC-LINKAGE MAP OF THE BOVINE GENOME [J].

BARENDSE, W ;

ARMITAGE, SM ;

KOSSAREK, LM ;

SHALOM, A ;

KIRKPATRICK, BW ;

RYAN, AM ;

CLAYTON, D ;

LI, L ;

NEIBERGS, HL ;

ZHANG, N ;

GROSSE, WM ;

WEISS, J ;

CREIGHTON, P ;

MCCARTHY, F ;

RON, M ;

TEALE, AJ ;

FRIES, R ;

MCGRAW, RA ;

MOORE, SS ;

GEORGES, M ;

SOLLER, M ;

WOMACK, JE ;

HETZEL, DJS .

NATURE GENETICS, 1994, 6 (03) :227-235

[2]

CHUMAKOV IM, 1995, NATURE, V377, P175

[3] A GENETIC-MAP OF THE MOUSE WITH 4,006 SIMPLE SEQUENCE LENGTH POLYMORPHISMS [J].

DIETRICH, WF ;

MILLER, JC ;

STEEN, RG ;

MERCHANT, M ;

DAMRON, D ;

NAHF, R ;

GROSS, A ;

JOYCE, DC ;

WESSEL, M ;

DREDGE, RD ;

MARQUIS, A ;

STEIN, LD ;

GOODMAN, N ;

PAGE, DC ;

LANDER, ES .

NATURE GENETICS, 1994, 7 (02) :220-245

[4]

ELSNER TI, 1995, AM J HUM GENET, V56, P500

[5]

GERKEN SC, 1995, AM J HUM GENET, V56, P484

[6] THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP [J].

GYAPAY, G ;

MORISSETTE, J ;

VIGNAL, A ;

DIB, C ;

FIZAMES, C ;

MILLASSEAU, P ;

MARC, S ;

BERNARDI, G ;

LATHROP, M ;

WEISSENBACH, J .

NATURE GENETICS, 1994, 7 (02) :246-339

[7] AN STS-BASED MAP OF THE HUMAN GENOME [J].

HUDSON, TJ ;

STEIN, LD ;

GERETY, SS ;

MA, JL ;

CASTLE, AB ;

SILVA, J ;

SLONIM, DK ;

BAPTISTA, R ;

KRUGLYAK, L ;

XU, SH ;

HU, XT ;

COLBERT, AME ;

ROSENBERG, C ;

REEVEDALY, MP ;

ROZEN, S ;

HUI, L ;

WU, XY ;

VESTERGAARD, C ;

WILSON, KM ;

BAE, JS ;

MAITRA, S ;

GANIATSAS, S ;

EVANS, CA ;

DEANGELIS, MM ;

INGALLS, KA ;

NAHF, RW ;

HORTON, LT ;

ANDERSON, MO ;

COLLYMORE, AJ ;

YE, WJ ;

KOUYOUMJIAN, V ;

ZEMSTEVA, IS ;

TAM, J ;

DEVINE, R ;

COURTNEY, DF ;

RENAUD, MT ;

NGUYEN, H ;

OCONNOR, TJ ;

FIZAMES, C ;

FAURE, S ;

GYAPAY, G ;

DIB, C ;

MORISSETTE, J ;

ORLIN, JB ;

BIRREN, BW ;

GOODMAN, N ;

WEISSENBACH, J ;

HAWKINS, TL ;

FOOTE, S ;

PAGE, DC .

SCIENCE, 1995, 270 (5244) :1945-1954

[8] A GENETIC-LINKAGE MAP OF THE LABORATORY RAT, RATTUS-NORVEGICUS [J].

JACOB, HJ ;

BROWN, DM ;

BUNKER, RK ;

DALY, MJ ;

DZAU, VJ ;

GOODMAN, A ;

KOIKE, G ;

KREN, V ;

KURTZ, T ;

LERNMARK, A ;

LEVAN, G ;

MAO, YP ;

PETTERSSON, A ;

PRAVENEC, M ;

SIMON, JS ;

SZPIRER, C ;

SZPIRER, J ;

TROLLIET, MR ;

WINER, ES ;

LANDER, ES .

NATURE GENETICS, 1995, 9 (01) :63-69

[9] CONSTRUCTION OF MULTILOCUS GENETIC-LINKAGE MAPS IN HUMANS [J].

LANDER, ES ;

GREEN, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2363-2367

[10]

LATHROP GM, 1984, AM J HUM GENET, V36, P460

← 1 2 3 →