TAS-102, the first "cardio-gentle" fluoropyrimidine in the colorectal cancer landscape?

被引：19
作者：
Petrelli, Fausto [1 ]
Barni, Sandro [1 ]
Bertocchi, Paola [2 ]
Zaniboni, Alberto [2 ]
机构：
[1] Azienda Osped Treviglio, Div Med Oncol, Dept Oncol, Piazzale Osped 1, I-24047 Treviglio, BG, Italy
[2] Fdn Poliambulanza, Dept Oncol, Via Bissolati 57, I-25100 Brescia, Italy
来源：
BMC CANCER | 2016年 / 16卷
关键词：
TAS-102; Cardiotoxicity; Fluoropyrimidines; JAPANESE PATIENTS; SOLID TUMORS; PHASE-I; 5-FLUOROURACIL; CARDIOTOXICITY; CAPECITABINE; TRIAL;
D O I：
10.1186/s12885-016-2409-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Cardiotoxicity in the form of cardiac arrhythmia, myocardial infarction, and angina-like symptoms are not rare complications of fluoropyrimidines as 5-Fluorouracil (5FU) and capecitabine. Discussion: Tas-102, a novel oral fluoropyrimidine, was recently approved by FDA for the treatment of advanced and refractory colorectal cancer. Its unique mechanism of action doesn't seem linked with cardiotoxicity in clinical trials reported so far. Summary: TAS 102 may represent one of the drugs of choice for patients with advanced colorectal cancer with cardiac disease. This intriguing and clinically relevant issue is briefly examined.
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页数：4
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