Silicon-stereogenic silanes in asymmetric catalysis

The exploitation of chirality at silicon in asymmetric catalysis is a challenging task. Silicon-stereogenic silanes were initially utilized to elucidate the stereochemical course of substitution at silicon. These mechanistic investigations are to be seen alongside a handful of synthetic transformations with covalently bound silicon as the stercoinducer. While in these substrate-controlled reactions the asymmetrically Substituted silicon functions as a chiral auxiliary, reagent-controlled processes have remained elusive. This account Summarizes the aimed design of silicon-stereogenic silanes and their introduction to stereoselective synthesis as chiral reagents.