Amine-functionalized mesoporous silica KIT 6 as a controlled release drug delivery carrier

被引：74

作者：

Ayad, Mohamad M. ^{[1
,2
]}

Salahuddin, Nehal A. ^{[1
]}

Abu El-Nasr, Ahmed ^{[1
]}

Torad, Nagy L. ^{[1
]}

机构：

[1] Tanta Univ, Fac Sci, Dept Chem, Tanta, Egypt

[2] Egypt Japan Univ Sci & Technol, Sch Basic & Appl Sci, New Borg El Arab City 21934, Alexandria, Egypt

来源：

MICROPOROUS AND MESOPOROUS MATERIALS | 2016年 / 229卷

关键词：

Mesoporous silica KIT-6; Sol-gel method; Drug delivery; Quartz crystal microbalance (QCM); TRIBLOCK COPOLYMER; MOLECULAR-SIEVE; NANOPARTICLES; CARBON; ADSORPTION; SYSTEMS; EPOXIDATION; COMPLEXES; CATALYSTS; DESIGN;

D O I：

10.1016/j.micromeso.2016.04.029

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Mesoporous silica KIT-6, has been prepared through the sol-gel method followed by a chemical modification using 3-aminopropyl triethoxysilane (APTS) to obtain KIT-6-NH2 as a drug delivery carrier. The mesostructure properties was fully characterized by transmission electron microscope (TEM), N-2 sorption isotherm, Fourier transform infrared (FT-IR), low-angel X-ray diffraction (XRD) and small-angel x-ray scattering (SAXS). Loading of ketoprofen (KP) and 5-flurouracil (5-FU) drugs as models into KIT-6 and KIT-6-NH2 was studied using quartz crystal microbalance (QCM) and UV visible spectroscopy. The loading uptake and release behaviors of KP and 5-FU were highly dependent on the textural properties of KIT-6 and KIT-6-NH2. The release of drugs was carefully studied in simulated gastric fluid (pH 2) and in simulated intestinal fluid (pH 7.4). First order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas release kinetic models were applied to the experimental data and the release was found to obey a first-order rate kinetic. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：166 / 177

页数：12

共 72 条

[1] Adsorption of phenolic compounds from aqueous solutions using functionalized SBA-15 as a nano-sorbent [J].