Risk of infection and death among post-splenectomy patients

被引:381
作者
Bisharat, N [1 ]
Omari, H
Lavi, I
Raz, R
机构
[1] Ha Emek Med Ctr, Rappaport Fac Med, Infect Dis Unit, IL-18101 Afula, Israel
[2] French Hosp, Dept Pediat, Nazareth, Israel
[3] Carmel Hosp, Rappaport Fac Med, Dept Community Hlth & Epidemiol, Haifa, Israel
关键词
D O I
10.1053/jinf.2001.0904
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: The true incidence of post-splenectomy sepsis remains undetermined. Methods: An English literature review on post-splenectomy sepsis was undertaken by means of databases of MEDLINE for the period 1966-96. The data registered included age at splenectomy, indication for splenectomy, incidence of infection and death, interval between splenectomy and infection, and microbial aetiology. Results: The reports include 19 680 patients having undergone splenectomy with a median follow up of 6.9 years. The incidence of infection after splenectomy was 3.2% and the mortality rate was 1.4%. Only 6942 reports were sufficiently detailed to allow useful analysis. The incidence of infection among children and adults was similar, 3.3% and 3.2%. respectively. However, the death rates among children were higher than adults (1.7% vs. 1.3%). The incidence of infection was highest among patients with thalassemia major (8.2%), and sickle-cell anaemia (7.3%). The highest mortality rates were observed among patients with thalassaemia major (5.1%), and sickle-cell anaemia (4.8%). Conclusion: The incidence of sepsis among post-splenectomy patients is low, however, it carries a high mortality rate especially among children with hematological disorders. (C) 2001 The British Infection Society.
引用
收藏
页码:182 / 186
页数:5
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