Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

被引：4

作者：

Yao, Shuyi ^{[1
]}

Xie, Hui ^{[2
]}

Zhang, Li ^{[1
]}

Meng, Tao ^{[1
]}

Zhang, Yongliang ^{[1
]}

Wang, Xin ^{[1
]}

Chen, Lin ^{[1
]}

Pan, Shengli ^{[2
]}

Shen, Jingkang ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China

来源：

MOLECULES | 2012年 / 17卷 / 02期

关键词：

laetispicine derivatives; antidepressant; total synthesis; forced swimming test;

D O I：

10.3390/molecules17021425

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first total synthesis of laetispicine (1a), an amide alkaloid isolated from the stems of Piper laetispicum C. DC (Piperaceae), and the synthesis of some of its derivatives were described. Based on the evaluation of antidepressant activities in the forced swimming test, compounds 1h and 1i were identified as potent and safe antidepressant lead compounds.

引用

页码：1425 / 1436

页数：12

共 14 条

[1] Alternative synthesis of cystothiazole A
Akita, Hiroyuki
Sutou, Noriyuki
Sasaki, Takamitsu
Kato, Keisuke
[J]. TETRAHEDRON, 2006, 62 (50) : 11592 - 11598
[2] The synthesis of two furan-based analogues of the α′,β′-epoxy ketone proteasome inhibitor eponemycin
Bennacer, B
Trubuil, D
Rivalle, C
Grierson, DS
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (23) : 4561 - 4568
[3] Blakemore PR, 1998, SYNLETT, P26
[4] Butler MS, 2005, NAT PROD REP, V22, P162, DOI 10.1039/b402985m
[5] Synthesis of medium- and large-sized lactones in an aqueous-organic biphasic system
Kinoshita, H
Shinokubo, H
Oshima, K
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (16) : 2397 - 2400
[6] Safrole-induced oxidative damage in the liver of Sprague-Dawley rats
Liu, TY
Chen, CC
Chen, CL
Chi, CW
[J]. FOOD AND CHEMICAL TOXICOLOGY, 1999, 37 (07) : 697 - 702
[7] Medicinal plant extracts for the treatment of dementia - A review of their pharmacology, efficacy and tolerability
Mantle, D
Pickering, AT
Perry, EK
[J]. CNS DRUGS, 2000, 13 (03) : 201 - 213
[8] Pan S.L., 2004, U.S. Patent, Patent No. [6,858,648 B2, 6858648]
[9] Pan S.L., 2006, WO, Patent No. 2006000158
[10] Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11
Park, CH
Choi, SH
Koo, JW
Seo, JH
Kim, HS
Jeong, SJ
Suh, YH
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) : 484 - 492

← 1 2 →