Motor symptoms in Parkinson's disease: A unified framework

被引：285

作者：

Moustafa, Ahmed A. ^{[1
,2
,3
]}

Chakravarthy, Srinivasa ^{[4
]}

Phillips, Joseph R. ^{[2
,3
]}

Gupta, Ankur ^{[4
]}

Keri, Szabolcs ^{[5
,6
,7
]}

Polner, Bertalan ^{[5
,6
]}

Frank, Michael J. ^{[8
]}

Jahanshahi, Madan ^{[9
,10
]}

机构：

[1] New Jersey Hlth Care Syst, Dept Vet Affairs, E Orange, NJ USA

[2] Univ Western Sydney, Sch Social Sci & Psychol, Sydney, NSW, Australia

[3] Univ Western Sydney, Marcs Inst Brain & Behav, Sydney, NSW, Australia

[4] Indian Inst Technol, Dept Biotechnol, Madras, Tamil Nadu, India

[5] Nyiro Gyula Hosp, Natl Inst Psychiat & Addict, Budapest, Hungary

[6] Budapest Univ Technol & Econ, Dept Cognit Sci, Budapest, Hungary

[7] Univ Szeged, Fac Med, Dept Physiol, Szeged, Hungary

[8] Brown Univ, Brown Inst Brain Sci, Dept Cognit Linguist Sci & Psychol Sci, Providence, RI 02912 USA

[9] Natl Hosp Neurol & Neurosurg London, UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, Cognit Motor Neurosci Grp, London, England

[10] Natl Hosp Neurol & Neurosurg London, UCL Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, Unit Funct Neurosurg, London, England

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2016年 / 68卷

关键词：

Parkinson's disease; Tremor; Akinesia; Bradykinesia; Rigidly; Freezing of gait; Handwriting; Grip force; Speech; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS STIMULATION; LEVODOPA-INDUCED DYSKINESIAS; UNPREDICTABLE PULLING LOADS; MILD COGNITIVE IMPAIRMENT; INTENSIVE VOICE TREATMENT; PRECISION GRIP FORCE; LONG-TERM DEPRESSION; BASAL GANGLIA NUCLEI; GRAY-MATTER ATROPHY;

D O I：

10.1016/j.neubiorev.2016.07.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Parkinson's disease (PD) is characterized by a range of motor symptoms. Besides the cardinal symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show additional motor deficits, including: gait disturbance, impaired handwriting, grip force and speech deficits, among others. Some of these motor symptoms (e.g., deficits of gait, speech, and handwriting) have similar clinical profiles, neural substrates, and respond similarly to dopaminergic medication and deep brain stimulation (DBS). Here, we provide an extensive review of the clinical characteristics and neural substrates of each of these motor symptoms, to highlight precisely how PD and its medical and surgical treatments impact motor symptoms. In conclusion, we offer a unified framework for understanding the range of motor symptoms in PD. We argue that various motor symptoms in PD reflect dysfunction of neural structures responsible for action selection, motor sequencing, and coordination and execution of movement. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：727 / 740

页数：14

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