Plasma kinetics and biodistribution of water-soluble CdTe quantum dots in mice: a comparison between Cd and Te

被引：15

作者：

Han, Ying ^{[1
]}

Xie, Guangyun ^{[1
,2
]}

Sun, Zhiwei ^{[1
]}

Mu, Ying ^{[3
]}

Han, Sihai ^{[3
]}

Xiao, Yang ^{[1
]}

Liu, Na ^{[1
]}

Wang, Hui ^{[1
]}

Guo, Caixia ^{[1
]}

Shi, Zhixiong ^{[1
]}

Li, Yanbo ^{[1
]}

Huang, Peili ^{[1
]}

机构：

[1] Capital Med Univ, Sch Publ Hlth & Family Med, Dept Toxicol & Sanit Chem, Beijing 100069, Peoples R China

[2] Chinese Ctr Dis Control & Prevent, Inst Occupat Hlth & Poisoning Control, Beijing 100013, Peoples R China

[3] Zhejiang Univ, Inst Cyber Syst & Control, State Key Lab Ind Control Technol, Res Ctr Analyt Instrumentat, Hangzhou 310058, Zhejiang, Peoples R China

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2011年 / 13卷 / 10期

关键词：

Quantum dot; Kinetics; Biodistribution; ICP-MS; Mice; Health effects; Nanomedicine; BAND-EDGE LUMINESCENCE; IN-VIVO; COLLOIDAL CDSE; CADMIUM TELLURIDE; NANOCRYSTALS; TOXICITY; PHOTOLUMINESCENCE; NANOPARTICLES; CYTOTOXICITY; QUANTUM-DOT-705;

D O I：

10.1007/s11051-011-0523-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water-soluble quantum dots (QDs) have shown potential as tumor diagnostic agents. However, little is known about their biological behaviors in vivo. Male ICR mice were intravenously given a single dose (2.5 mu mol kg(-1) body weight) of water-soluble cadmium-telluride (CdTe) QDs (the QDs are approximately 4 nm in diameter and have maximal emission at 630 nm). Inductively coupled plasma mass spectrometry (ICP-MS) was used for measuring the kinetic action of Cd-111 and Te-125 for 7 days. The plasma kinetics of Cd and Te followed a two-compartment model, in which Cd exhibited greater apparent volume of distribution, greater clearance, faster distribution half-life, and significantly slower elimination half-life compared to Te. Contrary to its relatively transient fate in the plasma, high levels of Cd persisted in the liver and kidneys. Te accumulated primarily in the spleen. The different plasma kinetics and distribution patterns of Cd and Te imply that CdTe QDs have been part of the degradation or aggregation in vivo.

引用

页码：5373 / 5380

页数：8

共 43 条

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