The relationship between obesity and hypoferraemia in adults: a systematic review

被引:122
作者
Cheng, H. L. [1 ]
Bryant, C. [2 ]
Cook, R. [1 ]
O'Connor, H. [1 ]
Rooney, K. [1 ]
Steinbeck, K. [3 ]
机构
[1] Univ Sydney, Fac Hlth Sci, Discipline Exercise & Sport Sci, Lidcombe, NSW 1825, Australia
[2] Royal Prince Alfred Hosp, Inst Haematol, Sydney, NSW, Australia
[3] Univ Sydney, Acad Dept Adolescent Med, Sydney, NSW 2006, Australia
关键词
Hepcidin; inflammation; iron deficiency; obesity; SERUM TRANSFERRIN RECEPTOR; Y GASTRIC BYPASS; IRON-DEFICIENCY; BILIOPANCREATIC DIVERSION; NUTRITIONAL CONSEQUENCES; WEIGHT-LOSS; HEPCIDIN; FERRITIN; CHILDREN; INFLAMMATION;
D O I
10.1111/j.1467-789X.2011.00938.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A growing number of studies suggest a potential link between obesity and altered iron metabolism. The purpose of this systematic review was to examine existing literature on iron status in obese populations. A comprehensive literature search was conducted. Included studies recruited participants = 18 years with a body mass index = 30 kg m-2 and provided descriptive statistics for haemoglobin or ferritin at a minimum. There were 25 studies meeting all eligibility criteria, of these 10 examined iron status in free-living obese individuals and 15 reported baseline iron biomarkers from bariatric surgery candidates. Non-obese comparison groups were used by 10 (40%) articles. In these, seven obese groups reported higher mean haemoglobin concentration; six reported significantly higher ferritin concentration; and four significantly lower transferrin saturation. Due to insufficient data, it was not possible to make conclusions regarding mean differences for soluble transferrin receptor (sTfR), hepcidin or C-reactive protein. Existing evidence suggests a tendency for higher haemoglobin and ferritin concentration and lower transferrin saturation in obesity. Alternation of iron biomarkers in obese populations may be a result of obesity-related inflammation and/or related comorbidities. Further research incorporating measurement of inflammatory cytokines, sTfR and hepcidin is required to confirm the impact of obesity on iron status.
引用
收藏
页码:150 / 161
页数:12
相关论文
共 63 条
[1]   Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch [J].
Aasheim, Erlend T. ;
Bjorkman, Sofia ;
Sovik, Torgeir T. ;
Engstrom, My ;
Hanvold, Susanna E. ;
Mala, Tom ;
Olbers, Torsten ;
Bohmer, Thomas .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 90 (01) :15-22
[2]   Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children [J].
Aeberli, I. ;
Hurrell, R. F. ;
Zimmermann, M. B. .
INTERNATIONAL JOURNAL OF OBESITY, 2009, 33 (10) :1111-1117
[3]  
Ahmed F, 2008, ASIA PAC J CLIN NUTR, V17, P40
[4]   PROSPECTIVE HEMATOLOGIC EVALUATION OF GASTRIC EXCLUSION SURGERY FOR MORBID-OBESITY [J].
AMARAL, JF ;
THOMPSON, WR ;
CALDWELL, MD ;
MARTIN, HF ;
RANDALL, HT .
ANNALS OF SURGERY, 1985, 201 (02) :186-193
[5]   Is Obesity a Risk Factor for Anemia? [J].
Anna, Kiran ;
Biyyani, Raja Shekhar Sappati ;
Veluru, Chandra ;
Mullen, Kevin .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 :S114-S114
[6]   Bariatric surgery can correct iron depletion in morbidly obese women: A link with chronic inflammation [J].
Anty, Rodolphe ;
Dahman, Monsef ;
Iannelli, Antonio ;
Gual, Philippe ;
Staccini-Myx, Aline ;
Ben Amor, Imed ;
Luciani, Nathalie ;
Saint-Paul, Marie-Christine ;
Huet, Pierre-Michel ;
Sadoul, Jean-Louis ;
Srai, Surjit Kaila S. ;
Unwin, Robert ;
Gugenheim, Jean ;
Le Marchand-Brustel, Yannick ;
Tran, Albert ;
Bekri, Soumeya .
OBESITY SURGERY, 2008, 18 (06) :709-714
[7]   Is obesity associated with anemia of chronic disease? A population-based study [J].
Ausk, Karlee J. ;
Ioannou, George N. .
OBESITY, 2008, 16 (10) :2356-2361
[8]   Changes in iron status during weight loss with very-low-energy diets [J].
Beard, J ;
Borel, M ;
Peterson, FJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 66 (01) :104-110
[9]   Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH [J].
Bekri, Soumeya ;
Gual, Philippe ;
Anty, Rodolphe ;
Luciani, Nathalie ;
Dahman, Monsef ;
Ramesh, Bala ;
Iannelli, Antonio ;
Staccini-Myx, Aline ;
Casanova, Dominique ;
Ben Amor, Imed ;
Saint-Paul, Marie-Christine ;
Huet, Pierre-Michel ;
Sadoul, Jean-Louis ;
Gugenheim, Jean ;
Srai, Surjit Kaila S. ;
Tran, Albert ;
Le Marchand-Brustel, Yannick .
GASTROENTEROLOGY, 2006, 131 (03) :788-796
[10]   Prophylactic iron supplementation after Roux-en-Y gastric bypass - A prospective, double-blind, randomized study [J].
Brolin, RE ;
Gorman, JH ;
Gorman, RC ;
Petschenik, AJ ;
Bradley, LB ;
Kenler, HA ;
Cody, RP .
ARCHIVES OF SURGERY, 1998, 133 (07) :740-744