A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells

被引：51

作者：

Li, Jin ^{[1
]}

Gao, Ying ^{[1
]}

Guo, Haoran ^{[1
]}

Li, Xiaokang ^{[2
]}

Tang, Haoyang ^{[3
]}

Li, Jian ^{[2
]}

Guo, Yuan ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Key Lab Synthet & Nat Fratct Mol Chem,Minist Educ, Xian 710127, Shaanxi, Peoples R China

[2] East China Univ Sci & Technol, Sch Pharm, Shanghai 20023Z, Peoples R China

[3] Xian Univ Posts & Telecommun, Sch Automat, Xian 710121, Shaanxi, Peoples R China

来源：

DYES AND PIGMENTS | 2019年 / 163卷

基金：

中国国家自然科学基金;

关键词：

Colorimetric and ratiometric; Fluorescent probe; Bisulfite; Real samples; Live-cell imaging; SULFUR-DIOXIDE DERIVATIVES; SO2; DERIVATIVES; HYPOCHLOROUS ACID; RATIONAL DESIGN; RAPID DETECTION; SULFITE; MITOCHONDRIA; FOOD;

D O I：

10.1016/j.dyepig.2018.12.009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An abnormal level of bisulfite can induce toxicological effects associated with lung cancer, cardiovascular and neurological disorders. Therefore, it is of significance to develop an effective fluorescent probe to detect bisulfite in living cells. Herein, a novel fluorescent probe QPCT, based on a 1,4-addition mechanism, was constructed for the colorimetric and ratiometric detection of bisulfite. QPCT displayed high selectivity and anti-interference ability to bisulfite over other anions and biothiols. The probe renders a sensitive ratiometric response to bisulfite with a remarkable fluorescence blue shift from 590 to 537 nm and the fluorescence ratio was linear with bisulfite concentration over the range of 0-120 mu M. More importantly, QPCT has been successfully applied to detect bisulfite in sugars and living A549 cells, which indicated that QPCT had a great capability for monitoring bisulfite in complex systems.

引用

页码：285 / 290

页数：6

共 37 条

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