Potential Directions in the Use of Graphene Nanomaterials in Pharmacology and Biomedicine (Review)

被引:7
作者
Kulakova, I. I. [1 ]
Lisichkin, G., V [1 ]
机构
[1] Moscow MV Lomonosov State Univ, Bldg 3,1 Lenin Hills, Moscow 119991, Russia
关键词
graphene; graphene oxide; targeted drug transport; hyperthermia; theranostics; gene transfection; antibacterial substances; PHOTOTHERMAL THERAPY; IN-VITRO; OXIDE; DELIVERY; DNA; CHALLENGES; NANOPARTICLES; OPPORTUNITIES; CYTOTOXICITY; NANOCARRIERS;
D O I
10.1007/s11094-022-02594-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
This article provides a brief review of the current scientific literature on the structure, properties, and preparation of graphene nanomaterials (GNM) and their potential uses in pharmacology and biomedicine. The most important members of the graphene family are graphene itself and its oxide. GNM have been shown to have a set of unique physicochemical properties and have been studied intensely as substances for targeted drug delivery, gene transfection, hyperthermia, etc. GNM are regarded as potential nanomaterials for making implants and prostheses, and also as antibacterial substances. Problems facing researchers and requiring solution for successful introduction of GNM into practice are discussed.
引用
收藏
页码:1 / 11
页数:11
相关论文
共 112 条
[1]   Escherichia coli bacteria reduce graphene oxide to bactericidal graphene in a self-limiting manner [J].
Akhavan, O. ;
Ghaderi, E. .
CARBON, 2012, 50 (05) :1853-1860
[2]   Toxicity of Graphene and Graphene Oxide Nanowalls Against Bacteria [J].
Akhavan, Omid ;
Ghaderi, Elham .
ACS NANO, 2010, 4 (10) :5731-5736
[3]  
Aleksenko AG., 2014, GRAPHENE
[4]   Advances in Nanocarriers for Anticancer Drugs Delivery [J].
Ali, Imran ;
Lone, Mohammad Nadeem ;
Suhail, Mohammad ;
Mukhtar, Sofi Danish ;
Asnin, Leonid .
CURRENT MEDICINAL CHEMISTRY, 2016, 23 (20) :2159-2187
[5]  
Ameri SK, 2016, IEEE ENG MED BIO, P4201, DOI 10.1109/EMBC.2016.7591653
[6]   Edge and confinement effects allow in situ measurement of size and thickness of liquid-exfoliated nanosheets [J].
Backes, Claudia ;
Smith, Ronan J. ;
McEvoy, Niall ;
Berner, Nina C. ;
McCloskey, David ;
Nerl, Hannah C. ;
O'Neill, Arlene ;
King, Paul J. ;
Higgins, Tom ;
Hanlon, Damien ;
Scheuschner, Nils ;
Maultzsch, Janina ;
Houben, Lothar ;
Duesberg, Georg S. ;
Donegan, John F. ;
Nicolosi, Valeria ;
Coleman, Jonathan N. .
NATURE COMMUNICATIONS, 2014, 5
[7]  
Banerjee A. N., 2016, GLOB J NANOMED, V1
[8]   Purified Neurons can Survive on Peptide-Free Graphene Layers [J].
Bendali, Amel ;
Hess, Lucas H. ;
Seifert, Max ;
Forster, Valerie ;
Stephan, Anne-Fleur ;
Garrido, Jose A. ;
Picaud, Serge .
ADVANCED HEALTHCARE MATERIALS, 2013, 2 (07) :929-933
[9]   Graphene: Safe or Toxic? The Two Faces of the Medal [J].
Bianco, Alberto .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (19) :4986-4997
[10]   Novel Multicomponent and Biocompatible Nanocomposite Materials Based on Few-Layer Graphenes Synthesized on a Gold/Hydroxyapatite Catalytic System with Applications in Bone Regeneration [J].
Biris, Alexandru R. ;
Mahmood, Meena ;
Lazar, Mihaela D. ;
Dervishi, Enkeleda ;
Watanabe, Fumiya ;
Mustafa, Thikra ;
Baciut, Grigore ;
Baciut, Mihaela ;
Bran, Simion ;
Ali, Syed ;
Biris, Alexandru S. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2011, 115 (39) :18967-18976