Granulocyte colony-stimulating factor-based stem cell mobilization in patients with sickle cell disease

被引：15

作者：

Rosenbaum, Cara ^{[1
,2
]}

Peace, David ^{[3
]}

Rich, Elizabeth ^{[1
,2
]}

Van Besien, Koen ^{[1
,2
]}

机构：

[1] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA

[2] Univ Chicago, Canc Res Ctr, Chicago, IL 60637 USA

[3] Univ Chicago, Dept Med, Div Hematol Oncol, Chicago, IL 60637 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2008年 / 14卷 / 06期

关键词：

stem cell mobilization; granulocyte colony stimulating factor; sickle cell disease;

D O I：

10.1016/j.bbmt.2008.03.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Granulocyte colony-stimulating factor (G-CSF) has been reported to exacerbate vaso-occlusive crises in sickle cell disease. It has been recommended to avoid its use for stem cell mobilization in this population, yet autologous transplant is the standard of care and at times a life-saving treatment for patients with various hematologic malignancies such as relapsed aggressive lymphoma or multiple myeloma. We report 5 cases of patients with sickle cell disease and related hemoglobinopathies who underwent granulocyte-colony stimulating factor (G-CSF)-mobilization of peripheral blood stem cells (PBSC). Three of them developed manageable vaso-occlusive pain symptoms requiring parenteral narcotics alone. The 2 others had no complications. These cases demonstrate that stem cell mobilization using G-CSF, although complicated and not without risk, is feasible in patients with sickle cell syndromes. (C) 2008 American Society for Blood and Marrow Transplantation.

引用

页码：719 / 723

页数：5

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