Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study

被引：15

作者：

Babiloni, Claudio ^{[1
,2
]}

Noce, Giuseppe ^{[3
]}

Ferri, Raffaele ^{[4
]}

Lizio, Roberta ^{[3
]}

Lopez, Susanna ^{[1
]}

Lorenzo, Ivan ^{[4
]}

Tucci, Federico ^{[1
]}

Soricelli, Andrea ^{[3
,5
]}

Zurron, Montserrat ^{[6
]}

Diaz, Fernando ^{[6
]}

Nobili, Flavio ^{[7
,8
]}

Arnaldi, Dario ^{[7
,8
]}

Fama, Francesco ^{[7
]}

Buttinelli, Carla ^{[9
]}

Giubilei, Franco ^{[9
]}

Cipollini, Virginia ^{[9
]}

Marizzoni, Moira ^{[10
]}

Guntekin, Bahar ^{[11
,12
]}

Yildirim, Ebru ^{[13
]}

Hanoglu, Lutfu ^{[14
]}

Yener, Gorsev ^{[15
]}

Gunduz, Duygu Hunerli ^{[16
]}

Onorati, Paolo ^{[1
]}

Stocchi, Fabrizio ^{[17
]}

Vacca, Laura ^{[17
]}

Maestu, Fernando ^{[18
]}

Frisoni, Giovanni B. ^{[10
,19
,20
,21
]}

Del Percio, Claudio ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

[2] San Raffaele Cassino, Cassino, FR, Italy

[3] IRCCS SDN, Naples, Italy

[4] Oasi Res Inst IRCCS, Troina, Italy

[5] Univ Naples Parthenope, Dept Motor Sci & Healthiness, Naples, Italy

[6] Univ Santiago de Compostela, Fac Psicol, Dept Psicol Expt, Santiago De Compostela, Spain

[7] IRCCS Osped Policlin San Martino, Clin Neurol, Genoa, Italy

[8] Univ Genoa, Dipartimento Neurosci Oftalmol Genet Riabilitaz &, Genoa, Italy

[9] Sapienza Univ Rome, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy

[10] IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[11] Istanbul Medipol Univ, Sch Med, Dept Biophys, Istanbul, Turkey

[12] Istanbul Medipol Univ, Clin Electrophysiol Neuroimaging & Neuromodulat L, REMER, Istanbul, Turkey

[13] Istanbul Medipol Univ, Vocat Sch, Program Electroneurophysiol, Istanbul, Turkey

[14] Istanbul Medipol Univ, Sch Med, Dept Neurol, Istanbul, Turkey

[15] Izmir Sch Econ, Fac Med, Izmir, Turkey

[16] Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkey

[17] IRCCS San Raffaele Pisana, Rome, Italy

[18] Univ Complutense Madrid, Fac Psicol, Dept Psicol Expt, Madrid, Spain

[19] Univ Hosp, Memory Clin, Geneva, Switzerland

[20] Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland

[21] Univ Geneva, Geneva, Switzerland

来源：

CEREBRAL CORTEX | 2022年 / 32卷 / 10期

关键词：

exact low-resolution brain electromagnetic source tomography (eLORETA); mild cognitive impairment due to Alzheimer's disease (ADMCI); resting state electroencephalographic (rsEEG) rhythms; sex; CORTICAL RHYTHMS; QUANTITATIVE EEG; SPECTRAL-ANALYSIS; WHITE-MATTER; BAND POWER; AGE; DONEPEZIL; DEMENTIA; GENDER; DIAGNOSIS;

D O I：

10.1093/cercor/bhab348

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.

引用

页码：2197 / 2215

页数：19

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