Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant

被引:39
作者
Thanasarakhan, Wish [1 ,2 ]
Kruanetr, Senee [6 ]
Deming, Richard L. [4 ]
Liawruangrath, Boonsom [3 ,5 ]
Wangkarn, Sunantha [1 ,2 ]
Liawruangrath, Saisunee [1 ,2 ,5 ]
机构
[1] Chiang Mai Univ, Dept Chem, Ctr Excellence Innovat Chem, Fac Sci, Chiang Mai 50200, Thailand
[2] Chiang Mai Univ, Mat Sci Res Ctr, Fac Sci, Chiang Mai 50200, Thailand
[3] Chiang Mai Univ, Dept Pharmaceut Chem, Fac Pharm, Chiang Ma 50200, Thailand
[4] Calif State Univ Fullerton, Dept Chem, Fac Chem & Biochem, Fullerton, CA 92831 USA
[5] Chiang Mai Univ, Sci & Technol Res Inst, Chiang Mai 50200, Thailand
[6] Mahasarakham Univ, Dept Chem, Fac Sci, Maha Sarakham 44150, Thailand
关键词
Sequential injection analysis; Spectrophotometry; Tetracycline and their residues; Cationic surfactant; Yttrium (III); Pharmaceuticals; Milk and honey; Home-made software; FLOW-INJECTION; CETYLPYRIDINIUM CHLORIDE; DRUG FORMULATIONS; CHLORTETRACYCLINE; OXYTETRACYCLINE; LUMINESCENCE; COMPLEXES; ASSAY; SERUM; ZINC;
D O I
10.1016/j.talanta.2011.03.087
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A sequential injection analysis (SIA) spectrophotometric method for determining tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) in different sample matrices were described. The method was based on the reaction between tetracyclines and yttrium (III) in weak basic micellar medium, yielding the light yellow complexes, which were monitored at 390, 392 and 395 nm, respectively. A cationic surfactant, cetyltrimethylammonium bromide (CTAB) was used to obtain the micellar system. The linear ranges of calibration graphs were between 1.0 x 10(-5) and 4 x 10(-4) mol L(-1), respectively. The molar absorptivities were 5.24 x 10(5), 4.98 x 10(4) and 4.78 x 10(4) L mol(-1) cm(-1). The detection limits (3 sigma) were between 4.9 x 10(-6) and 7.8 x 10(-6) mol L(-1) whereas the limit of quantitations (10 sigma) were between 1.63 x 10(-5) and 2.60 x 10(-5) mol L(-1) the interday and intraday precisions within a weak revealed as the relative standard deviations (R.S.D., n = 11) were less than 4%. The method was rapid with a sampling rate of over 60 samples h(-1) for the three drugs. The proposed method has been satisfactorily applied for the determination of tetracycline and its derivatives in pharmaceutical preparations together with their residues in milk and honey samples collected in Chiang Mai Province. The accuracy was found to be high as the Student's t-values were found to be less than the theoretical ones. The results were compared favorably with those obtained by the conventional spectrophotometric method. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1401 / 1409
页数:9
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