Efficacy of high-dose methylprednisolone as a first-line therapy in adult patients with idiopathic thrombocytopenic purpura

被引：30

作者：

Alpdogan, Ö ^{[1
]}

Budak-Alpdogan, T ^{[1
]}

Ratip, S ^{[1
]}

Firatli-Tuglular, T ^{[1
]}

Tanriverdi, S ^{[1
]}

Karti, S ^{[1
]}

Bayik, M ^{[1
]}

Akoglu, T ^{[1
]}

机构：

[1] Marmara Univ, Sch Med, Dept Haematol Immunol, TR-81190 Istanbul, Turkey

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 103卷 / 04期

关键词：

idiopathic thrombocytopenic purpura; high-dose methylprednisolone;

D O I：

10.1046/j.1365-2141.1998.01096.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fifty-seven adult patients with idiopathic thrombocytopenic purpura (ITP) were treated with either conventional-dose prednisolone (CDP) (1 mg/kg/d, 36 patients) or high-dose methylprednisolone (HDP) (30 mg/ kg/d, 21 patients), as first-line treatment. Patients in the HDP arm responded more rapidly (4.7 v 8.4 d), with a higher response rate (80% v 52.7%), and without severe side-effects. One quarter of the patients (3/12) who were nonresponsive to CDP achieved complete remission when they were treated with HDP. The findings suggest that HDP may be a more effective first-line treatment than CDP for adult ITP, and it may also be preferred for life-threatening cases of ITP. However, these results must be confirmed by a randomized study prior to any change in the current practice of employing CDP as first-line treatment for adult ITP.

引用

页码：1061 / 1063

页数：3