Cloning, characterization and comparative analysis of pig plasma apolipoprotein A-IV

被引：8

作者：

Navarro, MA

Acín, S

Iturralde, M

Calleja, L

Carnicer, R

Guzmán-García, MA

González-Ramón, N

Mata, P

Isabel, B

López-Bote, CJ

Lampreave, F

Piñeiro, A

Osada, J

机构：

[1] Univ Zaragoza, Fac Vet, Dept Bioquim & Biol Mol & Celular, E-50013 Zaragoza, Spain

[2] Fdn Jimenez Diaz, E-28040 Madrid, Spain

[3] Univ Complutense, Fac Vet, Dept Anim Prod, E-28040 Madrid, Spain

来源：

GENE | 2004年 / 325卷

关键词：

apolipoprotein A-IV; pig; liver; cDNA;

D O I：

10.1016/j.gene.2003.10.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pig apolipoprotein (apo) A-IV cDNA was cloned, characterized and compared to the human ortholog. Mature porcine apo A-TV consists of 362 amino acids and displays a 75.6% sequence identity with human protein. Pig apo A-IV is the smallest reported mammalian apo A-IV because it lacks the repeated motifs of glutamine and glutamic acid at the carboxyl terminus. A phylogenic tree of apo A-IV mammalian proteins reveals that porcine apo A-IV is more closely related to humans and primates than to rodents. This protein is highly hydrophobic and is mainly associated with lipoproteins. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：157 / 164

页数：8

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