Kinetics and mechanism of the reaction of [RuII(tpy)(pic)(H2O)]+ with KHSO5 in oxidative cleavage of DNA

被引：4

作者：

Chatterjee, Debabrata ^{[1
,2
]}

Sengupta, Ayon ^{[1
,2
]}

van Eldik, Rudi ^{[2
]}

机构：

[1] CSIR, Chem & Biomimet Grp, Cent Mech Engn Res Inst, Durgapur 713209, India

[2] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen, Germany

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2011年 / 64卷 / 01期

关键词：

Ruthenium; Oxone; Kinetics; DNA cleavage; POLYPYRIDYL COMPLEXES; ALCOHOLS; MODEL;

D O I：

10.1080/00958972.2010.538049

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reaction of [RuII(tpy)(pic)(H2O)]+ (1) with KHSO5 resulting in the formation of [RuIV(tpy)(pic)(O)]+ (2) was studied kinetically as a function of [KHSO5], temperature (15-35 degrees C), and pressure (10-30 MPa) at a fixed pH of 5.1 using spectrophotometric techniques. A suggested mechanism that is in agreement with the observed rate and activation parameters is presented. Complex 1 was found to induce DNA (pBluescript) cleavage in the presence of KHSO5, which proceeds via oxygen transfer from 2.

引用

页码：30 / 37

页数：8

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