Interleukin-18 among atrial fibrillation patients in the absence of structural heart disease

被引:67
作者
Luan, Ying [1 ,2 ]
Guo, Yuanyuan [1 ,2 ]
Li, Shufeng [1 ]
Yu, Bo [1 ]
Zhu, Sui [3 ]
Li, Shaojun [1 ]
Li, Ning [1 ]
Tian, Zhen [2 ]
Peng, Chenghai [1 ]
Cheng, Jiali [1 ]
Li, Qingsong [1 ]
Cui, Jinjin [1 ]
Tian, Ye [1 ,2 ]
机构
[1] Harbin Med Coll, Dept Cardiol, Affiliated Hosp 2, Harbin 150086, Peoples R China
[2] Harbin Med Coll, Dept Pathophysiol, Harbin 150081, Peoples R China
[3] Harbin Med Coll, Dept Epidemiol, Coll Publ Hlth, Harbin 150081, Peoples R China
来源
EUROPACE | 2010年 / 12卷 / 12期
基金
中国国家自然科学基金;
关键词
Atrial fibrillation; Inflammation; IL-18; MMP-9; Hs C-reactive protein; C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; CARDIOVASCULAR-DISEASE; CARDIOVERSION; INFLAMMATION; ARRHYTHMIAS; MAINTENANCE; PERSISTENCE; FAILURE; (IL)-18;
D O I
10.1093/europace/euq321
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inflammation plays a role in the genesis and perpetuation of atrial fibrillation (AF). Interleukin (IL)-18 is a pleiotropic proinflammatory cytokine with a central role in the inflammatory cascade. We hypothesize that the circulating IL-18 concentration is elevated in AF patients. In a case-control study design, 56 cases with AF and 26 controls were enrolled. All AF cases were categorized into paroxysmal and persistent AF or lone AF and AF with hypertension. Circulating levels of IL-18, tumour necrosis factor-alpha, high-sensitivity C-reactive protein, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP-1 were measured. In adjusted analyses, only age, MMP-9, and IL-18 were independently associated with AF, in which IL-18 had the most significant association (P = 0.0011, standardized estimate &bgr = 1.76, OR = 1.02, 95% confidence interval: 1.01-1.03). Interleukin-18 levels in persistent AF patients were higher than those in paroxysmal ones (P = 0.0011). Patients who developed AF within 24 h prior to sampling displayed a higher level of IL-18 than those with sinus rhythm (P = 0.0027). Interleukin-18 was positively correlated with left atrial diameter (r = 0.33, P = 0.0117). This study documents the elevated IL-18 in AF patients. Interleukin-18 may be superior to other inflammatory markers which are known to be elevated in AF.
引用
收藏
页码:1713 / 1718
页数:6
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