Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

被引：246
作者：
Ni, Shuaijian [1 ,2 ]
Yao, Houzong [1 ,2 ]
Wang, Lili [1 ,2 ]
Lu, Jun [1 ,2 ]
Jiang, Feng [1 ,2 ,3 ]
Lu, Aiping [1 ,2 ]
Zhang, Ge [1 ,2 ]
机构：
[1] HKBU, Sch Chinese Med, Inst Precis Med & Innovat Drug Discovery, Hong Kong 999077, Hong Kong, Peoples R China
[2] HKBU, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong 999077, Hong Kong, Peoples R China
[3] Ningbo Univ, Fac Mat Sci & Chem Engn, State Key Lab Base Novel Funct Mat & Preparat Sci, Ningbo 315211, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 08期
关键词：
nucleic acid aptamer; nuclease degradation; rapid excretion; binding affinity; chemical modification; IN-VITRO SELECTION; X-RAY DIFFRACTION; DNA APTAMERS; CRYSTAL-STRUCTURE; HIGH-AFFINITY; VASCULAR-PERMEABILITY; LYSOPHOSPHOLIPASE-D; ANTI-MUC1; APTAMER; BINDING RNA; STABILITY;
D O I：
10.3390/ijms18081683
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
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页数：21
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