Synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction

被引：10

作者：

Bakherad, Mohammad ^{[1
]}

Keivanloo, Au ^{[1
]}

Amin, Amir H. ^{[1
]}

Farkhondeh, Amir ^{[1
]}

机构：

[1] Shahrood Univ Technol, Fac Chem, Shahrood 3619995161, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2019年 / 25卷 / 01期

关键词：

1,2,3-triazole; Benzimidazole; Click reaction; ONE-POT SYNTHESIS; TERMINAL ALKYNES; AZIDE; DERIVATIVES; CYCLOADDITION; CONJUGATION; CHEMISTRY;

D O I：

10.1515/hc-2019-0016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50 degrees C. A broad range of aromatic azides were successfully reacted with n-propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.

引用

页码：122 / 129

页数：8

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