Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin

被引：23

作者：

Biliotti, Elisa ^{[1
]}

Franchi, Cristiana ^{[1
]}

Spaziante, Martina ^{[1
]}

Garbuglia, Anna Rosa ^{[2
]}

Volpicelli, Lorenzo ^{[1
]}

Palazzo, Donatella ^{[1
]}

De Angelis, Maurizio ^{[1
]}

Esvan, Rozenn ^{[1
]}

Taliani, Gloria ^{[1
]}

机构：

[1] Sapienza Univ Rome, Clin Trop Med, Dept Clin Med, Rome, Italy

[2] Natl Inst Infect Dis Lazzaro Spallanzani, Lab Virol, Rome, Italy

来源：

INFECTION | 2018年 / 46卷 / 05期

关键词：

Hepatitis E; Ribavirin; Sofosbuvir; Acute-on-chronic-liver-failure; Hepatitis C; E VIRUS-INFECTION; PATIENT;

D O I：

10.1007/s15010-018-1168-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

IntroductionHepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking.Case reportWe report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. Thetreatment was capable of rapidly inducing both HCV and HEV viral suppression.ConclusionIn conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.

引用

页码：725 / 727

页数：3

共 10 条

[1] Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient [J].

Donnelly, Mhairi C. ;

Imlach, Stuart N. ;

Abravanel, Florence ;

Ramalingam, Sandeep ;

Johannessen, Ingolfur ;

Petrik, Juraj ;

Fraser, Alistair R. ;

Campbell, John D. M. ;

Bramley, Peter ;

Dalton, Harry R. ;

Hayes, Peter C. ;

Kamar, Nassim ;

Simpson, Kenneth J. .

GASTROENTEROLOGY, 2017, 152 (01) :300-301

[2] Hepatitis E Virus Genotype 4 Outbreak, Italy, 2011 [J].

Garbuglia, Anna R. ;

Scognamiglio, Paola ;

Petrosillo, Nicola ;

Mastroianni, Claudio Maria ;

Sordillo, Pasquale ;

Gentile, Daniele ;

La Scala, Patrizia ;

Girardi, Enrico ;

Capobianchi, Maria R. .

EMERGING INFECTIOUS DISEASES, 2013, 19 (01) :110-114

[3] Ribavirin for Chronic Hepatitis E Virus Infection in Transplant Recipients [J].

Kamar, Nassim ;

Izopet, Jacques ;

Tripon, Simona ;

Bismuth, Michael ;

Hillaire, Sophie ;

Dumortier, Jerome ;

Radenne, Sylvie ;

Coilly, Audrey ;

Garrigue, Valerie ;

D'Alteroche, Louis ;

Buchler, Matthias ;

Couzi, Lionel ;

Lebray, Pascal ;

Dharancy, Sebastien ;

Minello, Anne ;

Hourmant, Maryvonne ;

Roque-Afonso, Anne-Marie ;

Abravanel, Florence ;

Pol, Stanislas ;

Rostaing, Lionel ;

Mallet, Vincent .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (12) :1111-1120

[4] Recent knowledge on hepatitis E virus in Suidae reservoirs and transmission routes to human [J].

Pavio, Nicole ;

Doceul, Virginie ;

Bagdassarian, Eugenie ;

Johne, Reimar .

VETERINARY RESEARCH, 2017, 48

[5] Fulminant liver failure from acute autochthonous hepatitis E in France:: description of seven patients with acute hepatitis E and encephalopathy [J].

Peron, J. M. ;

Bureau, C. ;

Poirson, H. ;

Mansuy, J. M. ;

Alric, L. ;

Selves, J. ;

Dupuis, E. ;

Izopet, J. ;

Vinel, J. P. .

JOURNAL OF VIRAL HEPATITIS, 2007, 14 (05) :298-303

[6] Treatment of autochthonous acute hepatitis E with short-term ribavirin: a multicenter retrospective study [J].

Peron, Jean Marie ;

Abravanel, Florence ;

Guillaume, Maeva ;

Gerolami, Rene ;

Nana, Jean ;

Anty, Rodolphe ;

Pariente, Alexandre ;

Renou, Christophe ;

Bureau, Christophe ;

Robic, Marie-Angele ;

Alric, Laurent ;

Vinel, Jean Pierre ;

Izopet, Jacques ;

Kamar, Nassim .

LIVER INTERNATIONAL, 2016, 36 (03) :328-333

[7]

Riveiro-Barciela M, 2015, J CLIN GASTROENTEROL, V49, P165, DOI 10.1097/MCG.0000000000000113

[8] Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin [J].

Thi, Viet Loan Dao ;

Debing, Yannick ;

Wu, Xianfang ;

Rice, Charles M. ;

Neyts, Johan ;

Moradpour, Darius ;

Gouttenoire, Jerome .

GASTROENTEROLOGY, 2016, 150 (01) :82-+

[9] Chronic hepatitis E in HIV/HBV coinfected patient: lack of power of sofosbuvir-ribavirin [J].

Todesco, Eve ;

Demeret, Sophie ;

Calin, Ruxandra ;

Roque-Afonso, Anne-Marie ;

Thibault, Vincent ;

Mallet, Vincent ;

Akhavan, Sepideh ;

Jaspard, Marie ;

Peytavin, Gilles ;

Poynard, Thierry ;

Katlama, Christine ;

Pourcher, Valerie .

AIDS, 2017, 31 (09) :1346-1348

[10] Sofosbuvir shows antiviral activity in a patient with chronic hepatitis E virus infection [J].

van der Valk, Marc ;

Zaaijer, Hans L. ;

Kater, Arnon P. ;

Schinkel, Janke .

JOURNAL OF HEPATOLOGY, 2017, 66 (01) :242-243

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