REPEATED COURSES OF GRANULOCYTE COLONY-STIMULATING FACTOR IN AMYOTROPHIC LATERAL SCLEROSIS: CLINICAL AND BIOLOGICAL RESULTS FROM A PROSPECTIVE MULTICENTER STUDY

被引：57

作者：

Chio, Adriano ^{[1
]}

Mora, Gabriele ^{[2
,19
]}

La Bella, Vincenzo ^{[3
]}

Caponnetto, Claudia ^{[4
]}

Mancardi, Gianluigi ^{[4
]}

Sabatelli, Mario ^{[5
]}

Siciliano, Gabriele ^{[6
]}

Silani, Vincenzo ^{[7
]}

Corbo, Massimo ^{[8
]}

Moglia, Cristina ^{[1
]}

Calvo, Andrea ^{[1
]}

Mutani, Roberto ^{[1
]}

Rutella, Sergio ^{[9
,10
]}

Gualandi, Francesca ^{[11
]}

Melazzini, Mario ^{[12
]}

Scime, Rosanna ^{[13
]}

Petrini, Mario ^{[8
,14
]}

Bondesan, Paola ^{[15
]}

Garbelli, Silvia ^{[16
]}

Mantovani, Stefania ^{[16
]}

Bendotti, Caterina ^{[17
]}

Tarella, Corrado ^{[18
]}

机构：

[1] Univ Turin, Dipartimento Neurosci, SC Neurol I & Ctr Sclerosi Laterale Amiotrof, I-10126 Turin, Italy

[2] IRCCS Fdn Salvatore Mattgeri, SC Neuroriabilitaz, Milan, Italy

[3] Univ Palermo, SC Neurol, Palermo, Italy

[4] Univ Genoa, Clin Neurol 2, Genoa, Italy

[5] Univ Cattolica Sacro Cuore, SC Neurol, Rome, Italy

[6] Univ Pisa, SC Neurol, Pisa, Italy

[7] Univ Milan, UO Neurol & Lab Neurosci, Ctr Dino Ferrari, IRCCS Ist Auxol Italiano, Milan, Italy

[8] NEuroMuscular Omnicentre NEMO, Milan, Italy

[9] Univ Cattolica Sacro Cuore, SC Ematologia, Rome, Italy

[10] IRCCS San Raffaele Pisana, Rome, Italy

[11] Univ San Martino, Ctr Trapianti Midollo, Div Ematol 2, Azienda Osped, Genoa, Italy

[12] Fdn Salvatore Maugeri, SC Oncoematol, Pavia, Italy

[13] Osped Cervello, Ctr Trapianti Miclollo Osseo, Palermo, Italy

[14] Univ Pisa, Div Ematol, Dipartimento Oncol Trapianti & Nuove Tecnol Med, Pisa, Italy

[15] AOU Giovanni Batista, SC Ematol, Turin, Italy

[16] IRCCS Fdn Salvatore Maugeri, Lab Malattie Neurodegenerat, Pavia, Italy

[17] Ist Ric Farmacol Mario Negri, Dipartimento Neurosci, Milan, Italy

[18] AO Mauriziano & Mol Biotechnol Ctr, Dipartimento Med Oncol Sperimentale, SCU Etnatol & Terapie Cellulari, Turin, Italy

[19] Univ Palermo, Ctr Reg Riferimento Malattie Motoneur, Palermo, Italy

来源：

MUSCLE & NERVE | 2011年 / 43卷 / 02期

关键词：

amyotrophic lateral sclerosis; clinical trial; granulocyte colony-stimulating factor; hematopoietic stem cells; neuroinflammation; PERIPHERAL-BLOOD; BONE-MARROW; SPINAL-CORD; STEM-CELLS; INTERLEUKIN-17; MOBILIZATION; SURVIVAL; IL-17; ALS; EXPRESSION;

D O I：

10.1002/mus.21851

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G-CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS patients entered an open-label, multicenter trial in which four courses of G-CSF and mannitol were administered at 3-month intervals. Levels of G-CSF Were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrease in ALSFRS-R score and forced vital capacity was observed. A significant reduction in CSF levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-17 (IL-17) was observed. G-CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP-1 and IL-17 was found, indicating a G-CSF-induced central anti-inflammatory response. Muscle Nerve 43: 189-195, 2011

引用

页码：189 / 195

页数：7

共 39 条

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