Synthesis of Molluscicidal Agent Cyanolide A Macrolactone from D-(-)-Pantolactone

被引：43

作者：

Hajare, Atul K. ^{[1
]}

Ravikumar, Velayutham ^{[1
]}

Khaleel, Shaik ^{[1
]}

Bhuniya, Debnath ^{[1
]}

Reddy, D. Srinivasa ^{[1
]}

机构：

[1] Advinus Therapeut Ltd, Discovery Chem, Pune 411057, Maharashtra, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 03期

关键词：

NATURAL-PRODUCT (-)-CLAVOSOLIDE-A; SPONGE MYRIASTRA-CLAVOSA; ENANTIOSPECIFIC SYNTHESIS; ABSOLUTE-CONFIGURATION; SCHISTOSOMIASIS; BRYOSTATINS; REDUCTION; MACROLIDE; FRAGMENT; RING;

D O I：

10.1021/jo101782q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of potent molluscicidal agent cyanolide A, a glycosidic 16-membered macrolide, starting from D-(-)-pantolactone is reported. Highly stereoselective aldol, oxa-Michael addition, and Yamaguchi macrolactonization are the key steps in the present synthesis.

引用

页码：963 / 966

页数：4

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