Filling in the GAPs in understanding RAS

被引:2
作者
Cox, Adrienne D. [1 ,2 ,3 ]
Der, Channing J. [1 ,3 ]
机构
[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, Dept Radiat Oncol, Chapel Hill, NC 27515 USA
[3] Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27515 USA
关键词
D O I
10.1126/science.abl3639
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:152 / 153
页数:2
相关论文
共 9 条
[1]   Acquired Resistance to KRASG12C Inhibition in Cancer [J].
Awad, M. M. ;
Liu, S. ;
Rybkin, I. I. ;
Arbour, K. C. ;
Dilly, J. ;
Zhu, V. W. ;
Johnson, M. L. ;
Heist, R. S. ;
Patil, T. ;
Riely, G. J. ;
Jacobson, J. O. ;
Yang, X. ;
Persky, N. S. ;
Root, D. E. ;
Lowder, K. E. ;
Feng, H. ;
Zhang, S. S. ;
Haigis, K. M. ;
Hung, Y. P. ;
Sholl, L. M. ;
Wolpin, B. M. ;
Wiese, J. ;
Christiansen, J. ;
Lee, J. ;
Schrock, A. B. ;
Lim, L. P. ;
Garg, K. ;
Li, M. ;
Engstrom, L. D. ;
Waters, L. ;
Lawson, J. D. ;
Olson, P. ;
Lito, P. ;
Ou, S. -H. I. ;
Christensen, J. G. ;
Janne, P. A. ;
Aguirre, A. J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (25) :2382-2393
[2]   The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients [J].
Hallin, Jill ;
Engstrom, Lars D. ;
Hargis, Lauren ;
Calinisan, Andrew ;
Aranda, Ruth ;
Briere, David M. ;
Sudhakar, Niranjan ;
Bowcut, Vickie ;
Baer, Brian R. ;
Ballard, Joshua A. ;
Burkard, Michael R. ;
Fell, Jay B. ;
Fischer, John P. ;
Vigers, Guy P. ;
Xue, Yaohua ;
Gatto, Sole ;
Fernandez-Banet, Julio ;
Pavlicek, Adam ;
Velastagui, Karen ;
Chao, Richard C. ;
Barton, Jeremy ;
Pierobon, Mariaelena ;
Baldelli, Elisa ;
Patricoin, Emanuel F., III ;
Cassidy, Douglas P. ;
Marx, Matthew A. ;
Rybkin, Igor I. ;
Johnson, Melissa L. ;
Ou, Sai-Hong Ignatius ;
Lito, Piro ;
Papadopoulos, Kyriakos P. ;
Janne, Pasi A. ;
Olson, Peter ;
Christensen, James G. .
CANCER DISCOVERY, 2020, 10 (01) :54-71
[3]   The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS [J].
Li, Chuanchuan ;
Vides, Alberto ;
Kim, Dongsung ;
Xue, Jenny Y. ;
Zhao, Yulei ;
Lito, Piro .
SCIENCE, 2021, 374 (6564) :197-+
[4]   Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism [J].
Lito, Piro ;
Solomon, Martha ;
Li, Lian-Sheng ;
Hansen, Rasmus ;
Rosen, Neal .
SCIENCE, 2016, 351 (6273) :604-608
[5]   Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials [J].
O'Brien, Joseph B. ;
Wilkinson, Joshua C. ;
Roman, David L. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (49) :18571-18585
[6]   K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions [J].
Ostrem, Jonathan M. ;
Peters, Ulf ;
Sos, Martin L. ;
Wells, James A. ;
Shokat, Kevan M. .
NATURE, 2013, 503 (7477) :548-+
[7]   Drugging RAS: Know the enemy [J].
Papke, Bjoern ;
Der, Channing J. .
SCIENCE, 2017, 355 (6330) :1158-1163
[8]   Clinical Acquired Resistance to KRASG12C Inhibition through a novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation [J].
Tanaka, Noritaka ;
Lin, Jessica J. ;
Li, Chendi ;
Ryan, Meagan B. ;
Zhang, Junbing ;
Kiedrowski, Lesli A. ;
Michel, Alexa G. ;
Syed, Mohammed U. ;
Fella, Katerina A. ;
Sakhi, Mustafa ;
Baiev, Islam ;
Juric, Dejan ;
Gainor, Justin F. ;
Klempner, Samuel J. ;
Lennerz, Jochen K. ;
Siravegna, Giulia ;
Bar-Peled, Liron ;
Hata, Aaron N. ;
Heist, Rebecca S. ;
Corcoran, Ryan B. .
CANCER DISCOVERY, 2021, 11 (08) :1913-1922
[9]   A CYTOPLASMIC PROTEIN STIMULATES NORMAL N-RAS P21 GTPASE, BUT DOES NOT AFFECT ONCOGENIC MUTANTS [J].
TRAHEY, M ;
MCCORMICK, F .
SCIENCE, 1987, 238 (4826) :542-545