Concise synthesis of stereodefined, thiazole -: containing cyclic hexa- and octapeptide relatives of the Lissoclinums, via cyclooligomerisation reactions

被引：36

作者：

Bertram, A ^{[1
]}

Blake, AJ ^{[1
]}

de Turiso, FGL ^{[1
]}

Hannam, JS ^{[1
]}

Jolliffe, KA ^{[1
]}

Pattenden, G ^{[1
]}

Skae, M ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

TETRAHEDRON | 2003年 / 59卷 / 35期

关键词：

Lissoclinum; cyclooligomerisation; thiazole;

D O I：

10.1016/S0040-4020(03)00821-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a range of thiazole containing cyclic peptides using cyclooligomerisation reactions of amino acid substituted thiazole monomers and by macrolactamisation procedures is reported. The synthetic approaches lead to high yields of novel 18- and 24-membered ring analogues of the naturally occurring Lissoclinum families of cyclic peptides found in marine organisms and algae. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6979 / 6990

页数：12

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