Selenium, Selenoproteins, and Immunity

被引：638

作者：

Avery, Joseph C. ^{[1
]}

Hoffmann, Peter R. ^{[1
]}

机构：

[1] Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, 651 Ilalo St, Honolulu, HI 96813 USA

来源：

NUTRIENTS | 2018年 / 10卷 / 09期

基金：

美国国家卫生研究院;

关键词：

selenocysteine; macrophage; T cell; antibody; inflammation; cancer; MITOCHONDRIAL THIOREDOXIN REDUCTASE; DEFICIENCY FACILITATES INFLAMMATION; EARLY EMBRYONIC LETHALITY; DISULFIDE BOND FORMATION; DIETARY SELENIUM; GLUTATHIONE-PEROXIDASE; OXIDATIVE STRESS; BREAST-CANCER; T-CELL; MICRONUTRIENT STATUS;

D O I：

10.3390/nu10091203

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25 members in humans that exhibit a wide variety of functions. The development of high-throughput omic approaches and novel bioinformatics tools has led to new insights regarding the effects of selenium and selenoproteins in human immuno-biology. Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. This review presents a summary of the current understanding of the role of selenium and selenoproteins in regulating immune cell functions and how dysregulation of these processes may lead to inflammation or immune-related diseases.

引用

页数：20

共 178 条

[1] The impacts of first line highly active antiretroviral therapy on serum selenium, cd4 count and body mass index: a cross sectional and short prospective study [J].

Akinboro, Adeolu Oladayo ;

Onayemi, Olaniyi ;

Ayodele, Olugbenga Edward ;

Mejiuni, Ayodele David ;

Atiba, Adeniran Samuel .

PAN AFRICAN MEDICAL JOURNAL, 2013, 15

[2] Improvement of leukocyte functions in young prematurely aging mice after a 5-week ingestion of a diet supplemented with biscuits enriched in antioxidants [J].

Alvarado, C ;

Alvarez, P ;

Jiménez, L ;

De la Fuente, M .

ANTIOXIDANTS & REDOX SIGNALING, 2005, 7 (9-10) :1203-1210

[3]

[Anonymous], 1991, Rep Health Soc Subj (Lond), V41, P1

[4] Serum Micronutrient Status of Haart-Naive, HIV Infected Children in South Western Nigeria: A Case Controlled Study [J].

Anyabolu, H. C. ;

Adejuyigbe, E. A. ;

Adeodu, O. O. .

AIDS RESEARCH AND TREATMENT, 2014, 2014

[5] Macrophage Bactericidal Activities against Staphylococcus aureus Are Enhanced In Vivo by Selenium Supplementation in a Dose-Dependent Manner [J].

Aribi, Mourad ;

Meziane, Warda ;

Habi, Salim ;

Boulatika, Yasser ;

Marchandin, Helene ;

Aymeric, Jean-Luc .

PLOS ONE, 2015, 10 (09)

[6] Methods of assessment of selenium status in humans: a systematic review [J].

Ashton, Kate ;

Hooper, Lee ;

Harvey, Linda J. ;

Hurst, Rachel ;

Casgrain, Amelie ;

Fairweather-Tait, Susan J. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2009, 89 (06) :2025S-2039S

[7] The treatment with selenium increases placental parasitismin pregnant Wistar rats infected with the Y strain of Trypanosoma cruzi [J].

Barbosa de Freitas, Murilo Rodrigues ;

Bronzon da Costa, Cassia Mariana ;

Pereira, Luiz Miguel ;

do Prado Junior, Jose Clovis ;

Sala, Miguel Angel ;

Carraro Abrahao, Ana Amelia .

IMMUNOBIOLOGY, 2018, 223 (10) :537-543

[8] Selenoproteins and oxidative stress-induced inflammatory tumorigenesis in the gut [J].

Barrett, Caitlyn W. ;

Short, Sarah P. ;

Williams, Christopher S. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2017, 74 (04) :607-616

[9] Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage [J].

Barrett, Caitlyn W. ;

Reddy, Vishruth K. ;

Short, Sarah P. ;

Motley, Amy K. ;

Lintel, Mary K. ;

Bradley, Amber M. ;

Freeman, Tanner ;

Vallance, Jefferson ;

Ning, Wei ;

Parang, Bobak ;

Poindexter, Shenika V. ;

Fingleton, Barbara ;

Chen, Xi ;

Washington, Mary K. ;

Wilson, Keith T. ;

Shroyer, Noah F. ;

Hill, Kristina E. ;

Burk, Raymond F. ;

Williams, Christopher S. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (07) :2646-2660

[10]

Baum MK, 1998, NUTR REV, V56, pS135

← 1 2 3 4 5 6 7 8 9 10 →