Study on the interactions of drug isoniazid in aqueous-D-xylose/L-arabinose solutions at different temperatures using volumetric, acoustic and viscometric approaches

Volumetric, acoustic and viscometric properties of drug isoniazid in water and aqueous solutions of carbohydrates, D-xylose and L-arabinose (5% and 10% D-xylose/L-arabinose in water, w/w) were studied at various temperatures, T = (293.15-318.15) K and at atmospheric temperature. The apparent molar volumes, V-phi and apparent molar compressibilities, K-s,K-phi were calculated from the experimentally measured densities and ultrasonic speeds. Limiting apparent molar volumes, V-phi(center dot), limiting apparent molar compressibilities, K-s,phi(center dot) limiting molar expansibilities, E-phi degrees and their corresponding transfer volumes, V-phi tr(center dot) and transfer compressibilities, K-s,phi,tr(center dot) of drug isoniazid from water to aqueous carbohydrate solutions were also evaluated. Falkenhagen Coefficients, A, Jones-Dole coefficients, B, variation of B with temperature, dB/dT, free energies of activation of viscous flow per mole of solvent, Delta mu(degrees#)(1) and per mole of solute, Delta mu(degrees#)(2) enthalpies, Delta H-degrees# and entropies, Delta S-center dot# of activation of viscous flow were calculated from the viscosity measurements. The negative sign of dB/dT indicated the structure making ability of the drug isoniazid. The results obtained have been discussed in terms of solute-solvent interactions in order to understand the solvation behaviour of isoniazid in these aqueous-carbohydrate solutions. (C) 2019 Elsevier B.V. All rights reserved.