The role of PACAP in the control of circadian expression of clock genes in the chicken pineal gland

被引：28

作者：

Nagy, Andras D. ^{[1
]}

Csernus, Valer J. ^{[1
]}

机构：

[1] Univ Pecs, Sch Med, Dept Anat, H-7633 Pecs, Hungary

来源：

PEPTIDES | 2007年 / 28卷 / 09期

关键词：

circadian; avian; pineal gland; PACAP; clock; Cry1; light;

D O I：

10.1016/j.peptides.2007.07.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several features of the molecular circadian oscillator of the chicken pineal gland show homology with those in the mammalian SCN. Studies have shown the effects of PACAP on the mammalian SCN, but its effects on the expression of clock genes in the avian pineal gland have not yet been demonstrated. Clock and Cry1 expression was analyzed in pineal glands of chicken embryos after exposure to PACAP-38 in vitro. PACAP reduced expression of both clock genes within 2 h. Ten hours after exposure, mRNA contents exceeded that of the controls. Our results support the hypothesis that the molecular clock machinery in the chicken pineal gland is also sensitive to PACAP. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1767 / 1774

页数：8

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