Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

被引：502
作者：
Becker, KG
Simon, RM
Bailey-Wilson, JE
Freidlin, B
Biddison, WE
McFarland, HF
Trent, JM
机构：
[1] Natl Human Genome Res Inst, Canc Genet Branch, NIH, Bethesda, MD 20892 USA
[2] NCI, Biometr Res Branch, NIH, Bethesda, MD 20892 USA
[3] NINDS, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA
[4] Natl Human Genome Res Inst, Sect Stat Genet, Ctr Inherited Dis Res, NIH, Baltimore, MD 21224 USA
[5] Emmes Corp, Potomac, MD 20854 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 17期
关键词：
D O I：
10.1073/pnas.95.17.9979
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Human autoimmune diseases are thought to develop through a complex combination of genetic and environmental factors. Genome-wide linkage searches of autoimmune and inflammatory/immune disorders have identified a large number of non-major histocompatibility complex loci that collectively contribute to disease susceptibility. A comparison was made of the linkage results from 23 published autoimmune or immune-mediated disease genome-wide scans. Human diseases included multiple sclerosis, Crohn's disease, familial psoriasis, asthma, and type-I diabetes (IDDM). Experimental animal disease studies included murine experimental autoimmune encephalomyelitis, rat inflammatory arthritis, rat and murine IDDM, histamine sensitization, immunity to exogenous antigens, and murine lupus (systemic lupus erythematosus; SLE). A majority (approximate to 65%) of the human positive linkages map nonrandomly into 18 distinct clusters. Overlapping of susceptibility loci occurs between different human immune diseases and by comparing conserved regions with experimental autoimmune/immune disease models. This nonrandom clustering supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes.
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页码：9979 / 9984
页数：6
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