Genistein as an anti-inflammatory agent

被引：203
作者：
Verdrengh, M
Jonsson, IM
Holmdahl, R
Tarkowski, A
机构：
[1] Gothenburg Univ, Dept Rheumatol & Inflammat Res, S-41346 Gothenburg, Sweden
[2] Lund Univ, Sect Med Inflammat Res, Lund, Sweden
来源：
INFLAMMATION RESEARCH | 2003年 / 52卷 / 08期
关键词：
collagen induced arthritis; granulocytes; lymphocytes; delayed type hypersensitivity reaction;
D O I：
10.1007/s00011-003-1182-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice. Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes.
引用
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页码：341 / 346
页数：6
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