Prevalence of the mcr-1 colistin resistance gene in extended-spectrum β-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China

被引：40

作者：

Bi, Zhenwang ^{[1
]}

Berglund, Bjorn ^{[2
]}

Sun, Qiang ^{[3
,4
]}

Nilsson, Maud ^{[2
]}

Chen, Baoli ^{[1
]}

Tarnberg, Maria ^{[2
]}

Ding, Lilu ^{[3
,4
]}

Lundborg, Cecilia Stalsby ^{[5
]}

Bi, Zhenqiang ^{[1
]}

Tomson, Goran ^{[5
,6
]}

Yao, Jingjing ^{[3
,4
]}

Gu, Zhanying ^{[3
,4
]}

Yin, Xiao ^{[7
]}

Kou, Zengqiang ^{[1
]}

Nilsson, Lennart E. ^{[2
]}

机构：

[1] Shandong Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China

[2] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden

[3] Shandong Univ, Ctr Hlth Management & Policy, 44Wenhua Xi Rd, Jinan, Shandong, Peoples R China

[4] Shandong Univ, Key Lab Hlth Econ & Policy Res, Minist Hlth, Jinan, Shandong, Peoples R China

[5] Karolinska Inst, Dept Publ Hlth Sci, Global Hlth Hlth Syst & Policy, Solna, Sweden

[6] Karolinska Inst, Dept Learning Informat Management & Eth, Solna, Sweden

[7] Jinan Cent Hosp, Jinan, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2017年 / 49卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Drug resistance; Bacteria; Colistin; Escherichia coli; Rural China; CARBAPENEM-RESISTANT; ANTIBIOTIC-RESISTANCE; ENTEROBACTERIACEAE; SURVEILLANCE; EMERGENCE;

D O I：

10.1016/j.ijantimicag.2016.12.018

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since its initial discovery in China in 2015, the plasmid-mediated colistin resistance gene mcr-1 has been reported in Escherichia coli isolated from clinical samples, animals and meat worldwide. In this study, 706 extended-spectrum beta-lactamase (ESBL)-producing E. coli from 411 persons were detected in a collection of faecal samples from 1000 rural residents in three counties in Shandong Province, China. These isolates were screened for mcr-1 and phenotypic colistin resistance. The gene was found in 3.5% of the isolates (from 4.9% of persons) from all three counties. All isolates with phenotypic colistin resistance carried mcr-1. These data indicate that commensal carriage of ESBL-producing E. coli with mcr-1 among persons in rural China was already present in 2012 and that mcr-1 was the most important colistin resistance mechanism. Interventions are necessary to minimise further dissemination of mcr-1, which would limit the future usefulness of colistin as a last-resort antibiotic. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

引用

页码：493 / 497

页数：5

共 20 条

[1] Detection of mcr-1 among Escherichia coli Clinical Isolates Collected Worldwide as Part of the SENTRY Antimicrobial Surveillance Program in 2014 and 2015 [J].

Castanheira, Mariana ;

Griffin, Michelle A. ;

Deshpande, Lalitagauri M. ;

Mendes, Rodrigo E. ;

Jones, Ronald N. ;

Flamm, Robert K. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (09) :5623-5624

[2] Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae [J].

Du, Hong ;

Chen, Liang ;

Tang, Yi-Wei ;

Kreiswirth, Barry N. .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :287-288

[3] Antibiotic resistance in China-a major future challenge [J].

Heddini, Andreas ;

Cars, Otto ;

Qiang, Sun ;

Tomson, Goran .

LANCET, 2009, 373 (9657) :30-30

[4] Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005-2014 [J].

Hu, F-P. ;

Guo, Y. ;

Zhu, D-M. ;

Wang, F. ;

Jiang, X-F. ;

Xu, Y-C. ;

Zhang, X-J. ;

Zhang, C-X. ;

Ji, P. ;

Xie, Y. ;

Kang, M. ;

Wang, C-Q. ;

Wang, A-M. ;

Xu, Y-H. ;

Shen, J-L. ;

Sun, Z-Y. ;

Chen, Z-J. ;

Ni, Y-X. ;

Sun, J-Y. ;

Chu, Y-Z. ;

Tian, S-F. ;

Hu, Z-D. ;

Li, J. ;

Yu, Y-S. ;

Lin, J. ;

Shan, B. ;

Du, Y. ;

Han, Y. ;

Guo, S. ;

Wei, L-H. ;

Wu, L. ;

Zhang, H. ;

Kong, J. ;

Hu, Y-J. ;

Ai, X-M. ;

Zhuo, C. ;

Su, D-H. ;

Yang, Q. ;

Jia, B. ;

Huang, W. .

CLINICAL MICROBIOLOGY AND INFECTION, 2016, 22 :S9-S14

[5] Susceptibility Testing of the Polymyxins: Where Are We Now? [J].

Humphries, Romney M. .

PHARMACOTHERAPY, 2015, 35 (01) :22-27

[6] Antibiotic resistance-the need for global solutions [J].

Laxminarayan, Ramanan ;

Duse, Adriano ;

Wattal, Chand ;

Zaidi, Anita K. M. ;

Wertheim, Heiman F. L. ;

Sumpradit, Nithima ;

Vlieghe, Erika ;

Levy Hara, Gabriel ;

Gould, Ian M. ;

Goossens, Herman ;

Greko, Christina ;

So, Anthony D. ;

Bigdeli, Maryam ;

Tomson, Goeran ;

Woodhouse, Will ;

Ombaka, Eva ;

Peralta, Arturo Quizhpe ;

Qamar, Farah Naz ;

Mir, Fatima ;

Kariuki, Sam ;

Bhutta, Zulfigar A. ;

Coates, Anthony ;

Bergstrom, Richard ;

Wright, Gerard D. ;

Brown, Eric D. ;

Cars, Otto .

LANCET INFECTIOUS DISEASES, 2013, 13 (12) :1057-1098

[7] Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study [J].

Liu, Yi-Yun ;

Wang, Yang ;

Walsh, Timothy R. ;

Yi, Ling-Xian ;

Zhang, Rong ;

Spencer, James ;

Doi, Yohei ;

Tian, Guobao ;

Dong, Baolei ;

Huang, Xianhui ;

Yu, Lin-Feng ;

Gu, Danxia ;

Ren, Hongwei ;

Chen, Xiaojie ;

Lv, Luchao ;

He, Dandan ;

Zhou, Hongwei ;

Liang, Zisen ;

Liu, Jian-Hua ;

Shen, Jianzhong .

LANCET INFECTIOUS DISEASES, 2016, 16 (02) :161-168

[8] Comparison of five rep-PCR genomic fingerprinting methods for differentiation of fecal Escherichia coli from humans, poultry and wild birds [J].

Mohapatra, Bidyut R. ;

Broersma, Klaas ;

Mazumder, Asit .

FEMS MICROBIOLOGY LETTERS, 2007, 277 (01) :98-106

[9] Early emergence of mcr-1 in Escherichia coli from food-producing animals [J].

Shen, Zhangqi ;

Wang, Yang ;

Shen, Yingbo ;

Shen, Jianzhong ;

Wu, Congming .

LANCET INFECTIOUS DISEASES, 2016, 16 (03) :293-293

[10] Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds [J].

Skov, R. L. ;

Monnet, D. L. .

EUROSURVEILLANCE, 2016, 21 (09) :2-7

← 1 2 →