homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum

被引：17

作者：

Ye, Ye ^{[1
,2
,3
]}

Yang, Xing-Wei ^{[1
]}

Zhou, Yan ^{[2
]}

Xu, Gang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Pr, Kunming 650201, Yunnan, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

FITOTERAPIA | 2019年 / 133卷

关键词：

Hypericum hookerianum; PPAPs; homo-Adamantane; Configuration; Cytotoxic activity; POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; PHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; UNIQUE FAMILY; SKELETON;

D O I：

10.1016/j.fitote.2018.12.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hookeriones I-Q (1-9), nine new homo-adamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum hookerianum, along with twenty known analogues. These structures were determined on the basis of comprehensive NMR and MS spectroscopic data. Comprehensive analysis of the NMR data revealed the correlations between the configuration of H-18 and H-28 and the chemical shifts of related signals. The cytotoxicity and anti-allergic activities of the new isolates were evaluated, and several ones exhibited moderate cytotoxicity against ECA-109 cell lines.

引用

页码：43 / 50

页数：8

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