homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum

被引：17
|
作者：
Ye, Ye [1 ,2 ,3 ]
Yang, Xing-Wei [1 ]
Zhou, Yan [2 ]
Xu, Gang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Pr, Kunming 650201, Yunnan, Peoples R China
[2] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
FITOTERAPIA | 2019年 / 133卷
关键词：
Hypericum hookerianum; PPAPs; homo-Adamantane; Configuration; Cytotoxic activity; POLYISOPRENYLATED BENZOYLPHLOROGLUCINOL DERIVATIVES; PHLOROGLUCINOL DERIVATIVES; BENZOPHENONE DERIVATIVES; UNIQUE FAMILY; SKELETON;
D O I：
10.1016/j.fitote.2018.12.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Hookeriones I-Q (1-9), nine new homo-adamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum hookerianum, along with twenty known analogues. These structures were determined on the basis of comprehensive NMR and MS spectroscopic data. Comprehensive analysis of the NMR data revealed the correlations between the configuration of H-18 and H-28 and the chemical shifts of related signals. The cytotoxicity and anti-allergic activities of the new isolates were evaluated, and several ones exhibited moderate cytotoxicity against ECA-109 cell lines.
引用
收藏
页码：43 / 50
页数：8
相关论文
共 50 条
  • [21] Hybeanones A and B, Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii
    Yang, Beiye
    Qi, Changxing
    Yao, Zeyu
    Lin, Shuang
    Li, Fengli
    Sun, Weiguang
    Hu, Zhengxi
    Zhang, Yonghui
    CHINESE JOURNAL OF CHEMISTRY, 2022, 40 (01): : 53 - 58
  • [22] Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity
    Li, Yanzhen
    Wang, Mingqiang
    Su, Jianhui
    Wang, Yuanyuan
    Zhao, Zhongxiang
    Sun, Zhanghua
    FITOTERAPIA, 2023, 169
  • [23] Four new polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii and their glucose uptake bioactivities
    Cheng, Haitao
    Zhang, Lulu
    Wang, Sisi
    Deng, Jingtong
    Zhou, Xiuteng
    Liu, Yang
    Yang, Xinzhou
    FITOTERAPIA, 2022, 159
  • [24] Hyperfols A and B: Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum perforatum
    Lou, Hua-Yong
    Li, Ya-Nan
    Yi, Ping
    Jian, Jun-You
    Hu, Zhan-Xing
    Gu, Wei
    Huang, Lie-Jun
    Li, Yan-Mei
    Yuan, Chun-Mao
    Hao, Xiao-Jiang
    ORGANIC LETTERS, 2020, 22 (17) : 6903 - 6906
  • [25] Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson
    Zhou, Zhong-Bo
    Shi, Wen-Pan
    Zeng, Hong
    Huang, You-Yi
    Wei, Xian
    Pan, Ke
    Teng, Li-Ping
    PHYTOCHEMISTRY LETTERS, 2022, 48 : 43 - 46
  • [26] Skeleton Reassignment of Type C Polycyclic Polyprenylated Acylphloroglucinols
    Yang, Xing-Wei
    Yang, Jing
    Xu, Gang
    JOURNAL OF NATURAL PRODUCTS, 2017, 80 (01): : 108 - 113
  • [27] Hypermogins A-D, four highly modified polycyclic polyprenylated acylphloroglucinols from Hypericum monogynum
    Zeng, Yanrong
    Yang, Jue
    Li, Yanan
    Gu, Wei
    Huang, Liejun
    Yi, Ping
    Yuan, Chunmao
    Hao, Xiaojiang
    TETRAHEDRON LETTERS, 2021, 64
  • [28] Polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum perforatum and absolute configurations assignment of previously reported analogues
    Guo, Yi
    Cao, Yunfang
    Qi, Changxing
    Tong, Qingyi
    Chen, Chunmei
    Yang, Jing
    Zhu, Hucheng
    Zhang, Yonghui
    BIOORGANIC CHEMISTRY, 2021, 114
  • [29] Hypermongones A-J, Rare Methylated Polycyclic Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum
    Xu, Wen-Jun
    Zhu, Meng-Di
    Wang, Xiao-Bing
    Yang, Ming-Hua
    Luo, Jun
    Kong, Ling-Yi
    JOURNAL OF NATURAL PRODUCTS, 2015, 78 (05): : 1093 - 1100
  • [30] Homoadamantane polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia multiflora
    Teng, Haida
    Ren, Yongshen
    Ma, Ziyu
    Tan, Xue
    Xu, Jing
    Chen, Yu
    Yang, Guangzhong
    FITOTERAPIA, 2019, 137
12345