Signals from the gut microbiota to distant organs in physiology and disease

被引：1032

作者：

Schroeder, Bjoern ^{[1
,2
]}

Backhed, Fredrik ^{[1
,2
,3
]}

机构：

[1] Univ Gothenburg, Wallenberg Lab, Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Dept Mol & Clin Med, Inst Med, Gothenburg, Sweden

[3] Univ Copenhagen, Sect Metab Receptol & Enteroendocrinol, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth Sci, Copenhagen, Denmark

来源：

NATURE MEDICINE | 2016年 / 22卷 / 10期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS; BUTYRATE-PRODUCING BACTERIA; ARYL-HYDROCARBON RECEPTOR; PROTEIN-COUPLED RECEPTOR; GLUCAGON-LIKE PEPTIDE-1; WHITE ADIPOSE-TISSUE; 16S RIBOSOMAL-RNA; INTESTINAL MICROBIOTA; BILE-ACID;

D O I：

10.1038/nm.4185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ecosystem of the human gut consists of trillions of bacteria forming a bioreactor that is fueled by dietary macronutrients to produce bioactive compounds. Thesd microbiota-derived metabolites signal to distant organs in the body, which enables the gut bacteria to connect to the immune and hormone system, to the brain (the gut brain axis) and to host metabolism, as well as other functions of the host. This microbe host communication is essential to maintain vital functions of the healthy host. Recently, however, the gut microbiota has been associated with a number of diseases, ranging from obesity and inflammatory diseases to behavioral and physiological abnormalities associated with neurodevelopmental disorders. In this Review, we will discuss microbiota-host cross-talk and intestinal microbiome signaling to extraintestinal organs. We will review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling might contribute to different diseases.

引用

页码：1079 / 1089

页数：11

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