Molecular analysis of the genetic variation among penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae serotypes in Canada

被引：32

作者：

Louie, M

Louie, L

Papia, G

Talbot, J

Lovgren, M

Simor, AE

机构：

[1] Univ Toronto, Dept Microbiol, Sunnybrook Dynacare Lab Serv, Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[2] Natl Ctr Streptococcus, Edmonton, AB, Canada

来源：

JOURNAL OF INFECTIOUS DISEASES | 1999年 / 179卷 / 04期

关键词：

D O I：

10.1086/314664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Few studies have examined the genetic relatedness,within and between serotypes of Streptococcus pneumoniae. Penicillin-susceptible S. pneumoniae (PSSP) isolates (n = 170) and penicillin-resistant SI pneumoniae (PRSP) isolates (n = 48) belonging to 13 different serotypes from across Canada were studied to further understand the molecular epidemiology of S. pneumoniae. PRSP of serotypes 6B, 14, and 19F appeared to be novel clones,;differentiated by pulsed-field gel electrophoresis from the recognized international penicillin-resistant clones belonging to these serotypes.:In addition, not all PRSP strains shared similar genetic backgrounds with PSSP strains of the same serotype,:suggesting that in Canada, certain PRSP strains have emerged from new unique lineages of PRSP. Although there was significant heterogeneity among S. pneumoniae of different serotypes, certain serotypes (3, 7F, and 22F) appeared to be more clonally related despite having originated from different geographic regions.

引用

页码：892 / 900

页数：9

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