Catalytic dehalogenation of aryl chlorides mediated by ruthenium(II) phosphine complexes

被引：66

作者：

Cucullu, ME

Nolan, SP

Belderrain, TR

Grubbs, RH ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Arnold & Mabel Beckman Lab Chem Synth, Pasadena, CA 91125 USA

[2] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

ORGANOMETALLICS | 1999年 / 18卷 / 07期

关键词：

D O I：

10.1021/om980682n

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The catalytic dechlorination of aryl chlorides performed by RuHCl(H-2)(2)(PCy3)(2) and RuH2(H-2)(2)(PCy3)(2) in alcohols is rapid and complete within 1 h. The mechanism involves a transfer hydrogenation step with participation of the alcohol. The system exhibits significant functional group tolerance. The catalyst can be generated in situ from [RuCl2(COD)](x) (COD = cyclooctadiene) and 2 equiv of phosphine (PCy3 or (PPr3)-Pr-i). Catalytic conversions are similar to those observed when an isolated precatalyst is used. Mechanistic considerations and the scope of the process are discussed.

引用

页码：1299 / 1304

页数：6

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