Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery

被引：81

作者：

Oezalp, Veli C. ^{[1
]}

Schaefer, Thomas ^{[1
,2
]}

机构：

[1] Univ Basque Country UPV EHU, Inst Polymer Mat POLYMAT, Donostia San Sebastian 20018, Spain

[2] Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 36期

基金：

欧洲研究理事会;

关键词：

aptamers; drug delivery; molecular gates; nanoparticles; nanovalves; stimuli-responsive nanoparticles; MESOPOROUS SILICA NANOPARTICLES; SENSORS; SYSTEMS;

D O I：

10.1002/chem.201101403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molecular gates: A new approach in developing controlled drug-delivery systems using aptamers as nanovalves is presented. For the proof of principle, mesoporous silica nanoparticles were modified with a hairpin form of ATP-binding DNA, which allows encapsulation and release of guest molecules controlled by ATP. This reversible aptamer-based nanogate function could provide novel trigger systems for any desired biological stimulus in drug-delivery applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9893 / 9896

页数：4

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