Aptamer-Based Switchable Nanovalves for Stimuli-Responsive Drug Delivery

被引:81
作者
Oezalp, Veli C. [1 ]
Schaefer, Thomas [1 ,2 ]
机构
[1] Univ Basque Country UPV EHU, Inst Polymer Mat POLYMAT, Donostia San Sebastian 20018, Spain
[2] Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain
基金
欧洲研究理事会;
关键词
aptamers; drug delivery; molecular gates; nanoparticles; nanovalves; stimuli-responsive nanoparticles; MESOPOROUS SILICA NANOPARTICLES; SENSORS; SYSTEMS;
D O I
10.1002/chem.201101403
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Molecular gates: A new approach in developing controlled drug-delivery systems using aptamers as nanovalves is presented. For the proof of principle, mesoporous silica nanoparticles were modified with a hairpin form of ATP-binding DNA, which allows encapsulation and release of guest molecules controlled by ATP. This reversible aptamer-based nanogate function could provide novel trigger systems for any desired biological stimulus in drug-delivery applications. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:9893 / 9896
页数:4
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