Photo-controllable bioorthogonal chemistry for spatiotemporal control of bio-targets in living systems

被引：54
作者：
Li, Jinbo [1 ]
Kong, Hao [1 ]
Zhu, Chenghong [1 ]
Zhang, Yan [1 ]
机构：
[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Jiangsu Key Lab Adv Organ Mat, Sch Chem & Chem Engn,Chem & Biomed Innovat Ctr Ch, Nanjing 210023, Peoples R China
来源：
CHEMICAL SCIENCE | 2020年 / 11卷 / 13期
基金：
中国国家自然科学基金;
关键词：
FREE CLICK CHEMISTRY; IN-VIVO; PROTECTING GROUPS; CROSS-LINKING; LIGATION; CYCLOADDITIONS; ALKYNYLATION; ACTIVATION; HYDROGELS; REAGENTS;
D O I：
10.1039/c9sc06540g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The establishment of bioorthogonal chemistry is one of the most significant advances in chemical biology using exogenous chemistry to perturb and study biological processes. Photo-modulation of biological systems has realized temporal and spatial control on biomacromolecules in living systems. The combination of photo-modulation and bioorthogonal chemistry is therefore emerging as a new direction to develop new chemical biological tools with spatiotemporal resolution. This minireview will focus on recent development of bioorthogonal chemistry subject to spatiotemporal control through photo-irradiation. Different strategies to realize photo-control on bioorthogonal bond-forming reactions and biological applications of photo-controllable bioorthogonal reactions will be summarized to give a perspective on how the innovations on photo-chemistry can contribute to the development of optochemical biology. Future trends to develop more optochemical tools based on novel photochemistry will also be discussed to envision the development of chemistry-oriented optochemical biology.
引用
收藏
页码：3390 / 3396
页数：7
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