Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients

被引：62

作者：

Ahlgren, Heather G. ^{[1
]}

Benedetti, Andrea ^{[1
,3
,4
]}

Landry, Jennifer S. ^{[1
,4
]}

Bernier, Joanie ^{[5
]}

Matouk, Elias ^{[1
,5
]}

Radzioch, Danuta ^{[1
,2
,6
]}

Lands, Larry C. ^{[7
]}

Rousseau, Simon ^{[1
,2
]}

Nguyen, Dao ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Med, Montreal, PQ, Canada

[2] McGill Univ, Dept Med, Res Inst, Ctr Hlth, Montreal, PQ, Canada

[3] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada

[4] McGill Univ, Ctr Hlth, Resp Epidemiol & Clin Res Unit, Montreal, PQ, Canada

[5] McGill Univ, Ctr Hlth, Adult CF clin, Montreal, PQ, Canada

[6] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[7] McGill Univ, Ctr Hlth, Res Inst, Dept Pediat, Montreal, PQ, Canada

来源：

BMC PULMONARY MEDICINE | 2015年 / 15卷

关键词：

Cystic fibrosis; Microbiology; Staphylococcus aureus; Pseudomonas aeruginosa; Lung function; Pulmonary exacerbation; Retrospective cohort; SMALL-COLONY VARIANTS; PULMONARY-FUNCTION; LUNG-DISEASE; YOUNG-CHILDREN; OROPHARYNGEAL CULTURES; SCORING SYSTEM; FEV1; DECLINE; INFANTS; INFLAMMATION; SURVIVAL;

D O I：

10.1186/s12890-015-0062-7

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Staphylococcus aureus (SA) is the most prevalent organism infecting the respiratory tract of CF children, and remains the second most prevalent organism in CF adults. During early childhood, SA infections are associated with pulmonary inflammation and decline in FEV1, but their clinical significance in adult CF patients is poorly characterized. Methods: We conducted a retrospective cross-sectional study to determine the association between airway microbiology and clinical outcomes (FEV1, rate of pulmonary exacerbations, CRP levels and clinical scores). Results: In a cohort of 84 adult CF patients, 24 % were infected with SA only, 60 % were infected with PA, and 16 % had neither PA nor SA. CF patients with SA experienced fewer pulmonary exacerbations and lower CRP levels than those with PA. Conclusion: In adult CF patients, SA infections alone, in the absence of PA, are a marker of milder disease.

引用

页数：6

共 44 条

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