Androgens and Breast Cancer in Men and Women

被引：23

作者：

Dimitrakakis, Constantine ^{[1
,2
]}

机构：

[1] NICHHD, Dev Endocrinol Branch, NIH, CRC, Bethesda, MD 20892 USA

[2] Univ Athens, Sch Med, Dept Obstet & Gynecol 1, Alexandra Hosp, Athens 11528, Greece

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2011年 / 40卷 / 03期

关键词：

Androgens; Testosterone; Breast cancer; Hormone therapy; Menopause; Male breast cancer; HORMONE-REPLACEMENT THERAPY; RANDOMIZED CONTROLLED-TRIAL; CAG REPEAT POLYMORPHISM; POSTMENOPAUSAL WOMEN; PROSTATE-CANCER; SEX-HORMONES; RISK-FACTORS; MAMMOGRAPHIC DENSITY; SERUM CONCENTRATIONS; PREMENOPAUSAL WOMEN;

D O I：

10.1016/j.ecl.2011.05.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abundant clinical evidence suggests that androgens normally inhibit mammary epithelial proliferation and breast growth. Clinical and nonhuman primate studies support the notion that androgens inhibit mammary proliferation and, thus, may protect from breast cancer. On the other hand, administration of conventional estrogen treatment suppresses endogenous androgens and may, thus, enhance estrogenic breast stimulation and possibly breast cancer risk. Addition of testosterone to the usual hormone therapy regimen may diminish the estrogen/progestin increase in breast cancer risk, but the impact of this combined use on mammary gland homeostasis still needs evaluation.

引用

页码：533 / +

页数：16

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