CXCR4-Based Imaging Agents

被引：51
作者：
Woodard, Lauren E. [1 ]
Nimmagadda, Sridhar [1 ]
机构：
[1] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA
来源：
JOURNAL OF NUCLEAR MEDICINE | 2011年 / 52卷 / 11期
关键词：
molecular imaging; metastasis; chemokine receptor; chemokine; cancer; CHEMOKINE RECEPTOR CXCR4; HUMAN CANCER XENOGRAFTS; BREAST-CANCER; EXPRESSION; TUMOR; CELLS; ANTAGONISTS; GROWTH; METASTASIS; INHIBITOR;
D O I：
10.2967/jnumed.111.097733
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Chemokine receptor 4 (CXCR4)-chemokine ligand 12 (CXCL12) interactions have been shown to play key roles in cancer cell survival, proliferation, chemotaxis, homing, adhesion, tumor angiogenesis, and resistance to conventional and targeted therapies. Given its extensive involvement in cancer progression, the CXCR4-CXCL12 axis has been considered a therapeutic target. Several inhibitors blocking this signaling cascade are in phase I trials. Because CXCR4 is constitutively expressed in a wide variety of normal tissues, patient stratification and noninvasive monitoring would improve therapeutic outcome and reduce unnecessary toxicities. This review focuses on recent developments in CXCR4-based imaging agents and their potential role in the molecular diagnosis and treatment of cancer.
引用
收藏
页码：1665 / 1669
页数：5
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  • [1] CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    Azab, Abdel Kareem
    Runnels, Judith M.
    Pitsillides, Costas
    Moreau, Anne-Sophie
    Azab, Feda
    Leleu, Xavier
    Jia, Xiaoying
    Wright, Renee
    Ospina, Beatriz
    Carlson, Alicia L.
    Alt, Clemens
    Burwick, Nicholas
    Roccaro, Aldo M.
    Ngo, Hai T.
    Farag, Mena
    Melhem, Molly R.
    Sacco, Antonio
    Munshi, Nikhil C.
    Hideshima, Teru
    Rollins, Barrett J.
    Anderson, Kenneth C.
    Kung, Andrew L.
    Lin, Charles P.
    Ghobrial, Irene M.
    [J]. BLOOD, 2009, 113 (18) : 4341 - 4351
  • [2] CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone
    Chinni, Sreenivasa R.
    Yamamoto, Hamilto
    Dong, Zhong
    Sabbota, Aaron
    Bonfil, R. Daniel
    Cher, Michael L.
    [J]. MOLECULAR CANCER RESEARCH, 2008, 6 (03) : 446 - 457
  • [3] Targeting the CXCR4/CXCL12 axis in systemic lupus erythematosus
    Chong, Benjamin F.
    Mohan, Chandra
    [J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2009, 13 (10) : 1147 - 1153
  • [4] Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil™) and potential of other CXCR4 antagonists as stem cell mobilizers
    De Clercq, Erik
    [J]. PHARMACOLOGY & THERAPEUTICS, 2010, 128 (03) : 509 - 518
  • [5] Imaging CXCR4 Expression in Human Cancer Xenografts: Evaluation of Monocyclam 64Cu-AMD3465
    De Silva, Ravindra A.
    Peyre, Kevin
    Pullambhatla, Mrudula
    Fox, James J.
    Pomper, Martin G.
    Nimmagadda, Sridhar
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2011, 52 (06) : 986 - 993
  • [6] CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration
    Decaillot, Fabien M.
    Kazmi, Manija A.
    Lin, Ying
    Ray-Saha, Sarmistha
    Sakmar, Thomas P.
    Sachdev, Pallavi
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (37) : 32188 - 32197
  • [7] PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
    Demmer, Oliver
    Gourni, Eleni
    Schumacher, Udo
    Kessler, Horst
    Wester, Hans-Juergen
    [J]. CHEMMEDCHEM, 2011, 6 (10) : 1789 - 1791
  • [8] CXCL12 (SDF1α)-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?
    Duda, Dan G.
    Kozin, Sergey V.
    Kirkpatrick, Nathaniel D.
    Xu, Lei
    Fukumura, Dai
    Jain, Rakesh K.
    [J]. CLINICAL CANCER RESEARCH, 2011, 17 (08) : 2074 - 2080
  • [9] CXCR4 and Matrix Metalloproteinase-1 Are Elevated in Breast Carcinoma-Associated Fibroblasts and in Normal Mammary Fibroblasts Exposed to Factors Secreted by Breast Cancer Cells
    Eck, Sarah M.
    Cote, Anik L.
    Winkelman, William D.
    Brinckerhoff, Constance E.
    [J]. MOLECULAR CANCER RESEARCH, 2009, 7 (07) : 1033 - 1044
  • [10] Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors
    Hanaoka, Hirofumi
    Mukai, Takahiro
    Tamamura, Hirokazu
    Mori, Tomohiko
    Ishino, Seigo
    Ogawa, Kazuma
    Iida, Yasuhiko
    Doi, Ryuichiro
    Fujii, Nobutaka
    Saji, Hideo
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2006, 33 (04) : 489 - 494
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