Liquid biopsy in non-small cell lung cancer: a key role in the future of personalized medicine?

被引：16

作者：

Pi, Can ^{[1
,2
,3
]}

Zhang, Ming-feng ^{[1
,2
,3
]}

Peng, Xiao-xiao ^{[1
,2
,4
]}

Zhang, Yi-chen ^{[1
,2
,3
]}

Xu, Chong-rui ^{[1
,2
]}

Zhou, Qing ^{[1
,2
,3
]}

机构：

[1] Guangdong Gen Hosp, Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China

[2] Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China

[3] Southern Med Univ, Sch Clin Med 2, Guangzhou, Guangdong, Peoples R China

[4] South China Univ Technol, Sch Med, Guangzhou, Guangdong, Peoples R China

来源：

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS | 2017年 / 17卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Liquid biopsy; ctDNA; non-small cell lung cancer; clinical application; personalised medicine; CIRCULATING TUMOR DNA; ESMO CLINICAL RECOMMENDATIONS; ACQUIRED-RESISTANCE; 1ST-LINE CRIZOTINIB; MUTATION ANALYSIS; EGFR MUTATIONS; OPEN-LABEL; PLASMA; CHEMOTHERAPY; HETEROGENEITY;

D O I：

10.1080/14737159.2017.1395701

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Introduction: Liquid biopsies, especially the analysis of circulating tumor DNA (ctDNA), as a novel and non-invasive method for the diagnosis and monitoring of non-small cell lung cancer (NSCLC) have already been implemented in clinical settings. The majority of ctDNA is released from apoptotic or necrotic tumor cells, thus reflecting the genetic profile of a tumor. Numerous studies have reported a high concordance in mutation profiles derived from liquid biopsy and tissue biopsy, especially in driver genes. Liquid biopsy could overcome the clonal heterogeneity of tumour biopsy, as it provides a single snapshot of a tumour tissue. Moreover, non-invasiveness is the biggest advantage for liquid biopsy, and the procedure can be repeatedly performed during the treatment for the purpose of monitoring. Therefore, ctDNA could act as a potential complementary method for tissue biopsies in diagnosis, prognostic, treatment response and resistance. Areas covered: This review summarizes the recent advancements in liquid biopsy with a focus on NSCLC, including its applications and technologies associated with assessing ctDNA. The authors conclude the review by discussing the challenges associated with liquid biopsy. Expert commentary: The analysis of ctDNA represents a promising method for liquid biopsy, which will be a novel and potentially complementary method in diagnosis, treatment and prognostic in NSCLC at all stages.

引用

页码：1089 / 1096

页数：8

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