Repairing the blood-brain barrier Engineered Wnt ligands specifically target blood-brain barrier function

被引:4
作者
McMahon, Andrew P. [1 ]
Ichida, Justin K. [1 ]
机构
[1] Univ Southern Calif, Keck Sch Med, Dept Stem Cell Biol & Regenerat Med, Los Angeles, CA 90007 USA
关键词
DISEASE;
D O I
10.1126/science.abn7921
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:715 / 716
页数:2
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共 14 条
  • [1] The blood-brain barrier and blood-tumour barrier in brain tumours and metastases
    Arvanitis, Costas D.
    Ferraro, Gino B.
    Jain, Rakesh K.
    [J]. NATURE REVIEWS CANCER, 2020, 20 (01) : 26 - 41
  • [2] Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation
    Cho, Chris
    Smallwood, Philip M.
    Nathans, Jeremy
    [J]. NEURON, 2017, 95 (05) : 1056 - +
  • [3] A molecular mechanism for Wnt ligand-specific signaling
    Eubelen, Marie
    Bostaille, Naguissa
    Cabochette, Pauline
    Gauquier, Anne
    Tebabi, Patricia
    Dumitru, Andra C.
    Koehler, Melanie
    Gut, Philipp
    Alsteens, David
    Stainier, Didier Y. R.
    Garcia-Pino, Abel
    Vanhollebeke, Benoit
    [J]. SCIENCE, 2018, 361 (6403) : 663 - +
  • [4] Structural Basis of Wnt Recognition by Frizzled
    Janda, Claudia Y.
    Waghray, Deepa
    Levin, Aron M.
    Thomas, Christoph
    Garcia, K. Christopher
    [J]. SCIENCE, 2012, 337 (6090) : 59 - 64
  • [5] Wnt/β-catenin signaling controls development of the blood-brain barrier
    Liebner, Stefan
    Corada, Monica
    Bangsow, Thorsten
    Babbage, Jane
    Taddei, Andrea
    Czupalla, Cathrin J.
    Reis, Marco
    Felici, Angelina
    Wolburg, Hartwig
    Fruttiger, Marcus
    Taketo, Makoto M.
    von Melchner, Harald
    Plate, Karl Heinz
    Gerhardt, Holger
    Dejana, Elisabetta
    [J]. JOURNAL OF CELL BIOLOGY, 2008, 183 (03) : 409 - 417
  • [6] Martin M., 2022, SCI, V375, DOI DOI 10.1126/SCIENCE.ABM4459
  • [7] Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module
    Munji, Roeben Nocon
    Soung, Allison Luen
    Weiner, Geoffrey Aaron
    Sohet, Fabien
    Semple, Bridgette Deanne
    Trivedi, Alpa
    Gimlin, Kayleen
    Kotoda, Masakazu
    Korai, Masaaki
    Aydin, Sidar
    Batugal, Austin
    Cabangcala, Anne Christelle
    Schupp, Patrick Georg
    Oldham, Michael Clark
    Hashimoto, Tomoki
    Noble-Haeusslein, Linda J.
    Daneman, Richard
    [J]. NATURE NEUROSCIENCE, 2019, 22 (11) : 1892 - +
  • [8] Post-Stroke Blood-Brain Barrier Disruption and Poor Functional Outcome in Patients Receiving Thrombolytic Therapy
    Nadareishvili, Zurab
    Simpkins, Alexis N.
    Hitomi, Emi
    Reyes, Dennys
    Leigh, Richard
    [J]. CEREBROVASCULAR DISEASES, 2019, 47 (3-4) : 135 - 142
  • [9] Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction
    Nation, Daniel A.
    Sweeney, Melanie D.
    Montagne, Axel
    Sagare, Abhay P.
    D'Orazio, Lina M.
    Pachicano, Maricarmen
    Sepehrband, Farshid
    Nelson, Amy R.
    Buennagel, David P.
    Harrington, Michael G.
    Benzinger, Tammie L. S.
    Fagan, Anne M.
    Ringman, John M.
    Schneider, Lon S.
    Morris, John C.
    Chui, Helena C.
    Law, Meng
    Toga, Arthur W.
    Zlokovic, Berislav V.
    [J]. NATURE MEDICINE, 2019, 25 (02) : 270 - +
  • [10] Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
    Nusse, Roel
    Clevers, Hans
    [J]. CELL, 2017, 169 (06) : 985 - 999