Structure of the NS3 helicase from Zika virus

被引：74

作者：

Jain, Rinku ^{[1
]}

Coloma, Javier ^{[1
]}

Garcia-Sastre, Adolfo ^{[2
,3
,4
]}

Aggarwal, Aneel K. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Struct & Chem Biol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 08期

关键词：

CRYSTAL-STRUCTURE; PROTEIN; DOMAIN;

D O I：

10.1038/nsmb.3258

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-angstrom) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.

引用

页码：752 / +

页数：4

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