Isolation of the Volatile Oil from Satureja thymbra by Supercritical Carbon Dioxide Extraction: Chemical Composition and Biological Activity

被引：0

作者：

Piras, Alessandra ^{[1
]}

Cocco, Viviana ^{[1
]}

Falconieri, Danilo ^{[1
]}

Porcedda, Silvia ^{[1
]}

Marongiu, Bruno ^{[1
]}

Maxia, Andrea ^{[2
,3
,4
]}

Frau, Maria Assunta ^{[2
,3
,4
]}

Goncalves, Maria J. ^{[5
]}

Cavaleiro, Carlos ^{[5
]}

Salgueiro, Ligia ^{[5
]}

机构：

[1] Univ Cagliari, Dipartimento Sci Chim, I-09042 Cagliari, Italy

[2] Univ Cagliari, CoSMeSe, I-09123 Cagliari, Italy

[3] Univ Cagliari, Dipartimento Sci Vita & Ambiente Macrosez Bot, I-09123 Cagliari, Italy

[4] Univ Cagliari, Orto Bot, I-09123 Cagliari, Italy

[5] Univ Coimbra, Fac Farm, Ctr Estudos Farmaceut, P-3000548 Coimbra, Portugal

来源：

NATURAL PRODUCT COMMUNICATIONS | 2011年 / 6卷 / 10期

关键词：

Satureja thymbra L; essential oil; supercritical CO2; antifungal activity; PLANTS GROWING WILD; CORIDOTHYMUS-CAPITATUS; ANTIMICROBIAL ACTIVITY; TURKEY; VARIABILITY; POPULATIONS; CRETE;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Satureja thymbra, L. is well known in Italy by the popular name of "Santoreggia sarda". It grows only in Sardinia and nowadays it is restricted to the slope of the Colic San Michele in Cagliari. The composition of the aromatic extracts obtained by supercritical CO2 and by hydrodistillation and their antifungal activity is reported. The collected extracts were analyzed by GC-FID and GC-MS methods. No significant differences were observed in the composition of the volatile extracts depending on the extraction method. The results showed the presence of thymol, gamma-terpinene, beta-caryophyllene, p-cymene, carvacrol and borneol as main components. The minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida albicans, C. tropicalis, C. krusei, C. guillermondii, C. parapsilosis, Cryptococcus neoformans, Trichophyton rubrum, T. mentagrophytes, T. mentagrophytes var. interdigitale, Trichophyton rubrum, T. verrucosum, Microsporum canis, M gypseum, Epidermophyton floccosum, Aspergillus niger, A. fumigatus and A. flaw's. The volatile extracts revealed a wide-spectrum antifungal activity. They were fungicidal and similarly potent against yeasts, dermatophyte and Aspergillus stains, with MICs ranging from 0.16 to 0.32 mu L.mL(-1).

引用

页码：1523 / 1526

页数：4

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