Celiac Disease in Children and Adolescents with Autoimmune Hepatitis: a Single-centre Experience

被引：18
作者：
El-Shabrawi, Mortada [1 ]
El-Karaksy, Hanaa [1 ]
Mohsen, Nabil [1 ]
Isa, Mona [1 ]
Al-Biltagi, Mohammed [2 ]
El-Ansari, Mervat [3 ]
机构：
[1] Cairo Univ, Dept Pediat, Fac Med, Cairo 11559, Egypt
[2] Tanta Univ, Dept Pediat, Fac Med, Tanta, Egypt
[3] Cairo Univ, Dept Clin Pathol, Fac Med, Cairo 11559, Egypt
来源：
JOURNAL OF TROPICAL PEDIATRICS | 2011年 / 57卷 / 02期
关键词：
Celiac disease; autoimmune hepatitis; Egypt; North Africa; TISSUE TRANSGLUTAMINASE; LIVER-DISEASE; DIAGNOSIS; PREVALENCE; POPULATION; ANTIBODIES; ASSAY;
D O I：
10.1093/tropej/fmq057
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Methods: We prospectively enrolled 26 AIH patients aged 3.5-21 (mean 9.98 +/- 3.94) years and 20 healthy age- and sex-matched controls. Serodiagnosis of CD was based on the most sensitive tests namely immunoglobulin A (IgA) human tissue transglutaminase antibody (IgA-tTGA) by enzyme-linked immunosorbent assay and/or IgA endomysial antibody (IgA-EMA) by immunofluoresence and confirmed the diagnosis by upper gastrointestinal endoscopy and histo-pathological findings in jejunal biopsy. Results: IgA-EMA was positive in four patients (15.4%), whereas IgA-tTGA was positive in two of them (7.7%). Histopathology was confirmatory in three (11.5%) seropositive patients. Conclusion: The high prevalence (11.5%) of CD among Egyptian children with AIH indicates that CD exists in high-risk groups in our region and must be carefully looked into.
引用
收藏
页码：104 / 108
页数：5
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