Human monocyte response to Andean-native starch nanoparticles

被引：8

作者：

Gatto, Francesca ^{[1
,2
]}

Troncoso, Omar P. ^{[3
]}

Brunetti, Virgilio ^{[4
]}

Malvindi, Maria Ada ^{[4
]}

Pompa, Pier Paolo ^{[1
]}

Torres, Fernando G. ^{[3
]}

Bardi, Giuseppe ^{[1
]}

机构：

[1] Ist Italiano Tecnol, Via Morego 30, I-16163 Genoa, Italy

[2] Univ Salento, Dept Engn Innovat, Lecce, Italy

[3] Pontificia Univ Catolica Peru, Dept Mech Engn, Lima, Peru

[4] Ist Italiano Tecnol, Ctr Biomol Nanotechnol UniLe, Lecce, Italy

来源：

STARCH-STARKE | 2016年 / 68卷 / 9-10期

关键词：

Inflammation; Monocytes; Nanoparticles; Starch; DRUG-DELIVERY SYSTEMS; TISSUE ENGINEERING SCAFFOLDS; ACID-TREATED STARCHES; BIOMEDICAL APPLICATIONS; POROUS STRUCTURES; HYDROGELS; FILMS; POLYMERS; CARRIERS; DISEASE;

D O I：

10.1002/star.201600105

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We used starches from two different Andean-native tubers to prepare nano-sized particles, and tested their ability to stimulate inflammatory reactions in human monocytes. Our data show that the release of inflammatory cytokines by monocytes can be differentially modulated by the administration of non-toxic doses of nanoparticles synthesized from the starch of the Andean sub-species Solanum tuberosum and Solanum goniocalyx. Furthermore, we observed a starch-nanoparticle-specific increase in inflammatory chemokine-dependent migration, and an up-regulation of immunoglobulin receptor CD16. Based on this preliminary study, we conclude that different potato starch nanoparticles possess specific properties that can induce immune responses and may be employed as immune modulators in the future.

引用

页码：1016 / 1023

页数：8

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