Impact of cardiac transplantation in 24 hours circadian blood pressure and heart rate profile

被引:12
作者
Kotsis, VT [1 ]
Stabouli, SV [1 ]
Pitiriga, VC [1 ]
Lekakis, JP [1 ]
Nanas, IN [1 ]
Toumanidis, ST [1 ]
Zakopoulos, NA [1 ]
机构
[1] Natl & Kapodestrial Univ, Alexandra Hosp, Dept Clin Therapeut, Athens, Greece
关键词
D O I
10.1016/j.transproceed.2005.03.087
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective. The aim of the present study was to evaluate 24 hours blood pressure (BP) and heart rate changes as well as 24-hour circadian BP rhythm of cardiac transplant recipients. Methods. Twenty-five transplant recipients and twenty-five healthy volunteers underwent 24-hour ambulatory BP monitoring. Parameters of 24-hour ambulatory BP monitoring (24-h/daytime/nightime systolic, diastolic BP, pulse pressure, and heart rate) were determined in all patients. Results. Clinic systolic/diastolic BP, mean 24-h systolic/diastolic BP, mean daytime systolic/diastolic BP, mean nighttime systolic/diastolic BP, and mean 24-h/daytime/nighttime heart rate were significantly higher in transplant recipients than in control group subjects. Standard deviations of 24-h/daytime/nighttime heart rates were significantly lower in transplant recipients. Dippers were 48% of the control and only 12% of the transplantation group. Conclusions. Cardiac transplant recipients had increased ambulatory BP. They also had increased 24-h/daytime/nighttime heart rate and decreased heart rate variability. Also, diminished nocturnal decrease of BP was found in transplant recipients.
引用
收藏
页码:2244 / 2246
页数:3
相关论文
共 16 条
[1]   THE 24-HOUR HEART-RATE BEHAVIOR IN LONG-TERM SURVIVORS OF CARDIAC TRANSPLANTATION [J].
ALEXOPOULOS, D ;
YUSUF, S ;
JOHNSTON, JA ;
BOSTOCK, J ;
SLEIGHT, P ;
YACOUB, MH .
AMERICAN JOURNAL OF CARDIOLOGY, 1988, 61 (11) :880-884
[2]  
ALEXOPOULOS D, 1989, EUR HEART J, V9, P1266
[3]   Conversion from cyclosporin A to tacrolimus is safe and decreases blood pressure, cholesterol levels and TGF-β1 type I receptor expression [J].
Baan, CC ;
van Riemsdijk-van Overbeeke, IC ;
Balk, AHMM ;
Vantrimpont, PMAJ ;
Mol, WM ;
Knoop, CJ ;
Niesters, HGM ;
Maat, LPWM ;
Weimar, W .
CLINICAL TRANSPLANTATION, 2001, 15 (04) :276-283
[4]   Role of sympathetic nervous system in cyclosporine-induced rise in blood pressure [J].
Carvalho, MJ ;
van den Meiracker, AH ;
Boomsma, F ;
Freitas, J ;
't Veld, AJMI ;
Costa, O ;
de Freitas, AF .
HYPERTENSION, 1999, 34 (01) :102-106
[5]   ABNORMAL DIURNAL-VARIATION OF BLOOD-PRESSURE, CARDIAC-OUTPUT, AND VASCULAR-RESISTANCE IN CARDIAC TRANSPLANT RECIPIENTS [J].
IDEMA, RN ;
VANDENMEIRACKER, AH ;
BALK, AHMM ;
BOS, E ;
SCHALEKAMP, MADH ;
TVELD, AJMI .
CIRCULATION, 1994, 90 (06) :2797-2803
[6]   CYCLOSPORINE THERAPY AFTER CARDIAC TRANSPLANTATION CAUSES HYPERTENSION AND RENAL VASOCONSTRICTION WITHOUT SYMPATHETIC ACTIVATION [J].
KAYE, D ;
THOMPSON, J ;
JENNINGS, G ;
ESLER, M .
CIRCULATION, 1993, 88 (03) :1101-1109
[7]  
Ligtenberg G, 2001, J AM SOC NEPHROL, V12, P368, DOI 10.1681/ASN.V122368
[8]   Study of arterial and autonomic effects of cyclosporine in humans [J].
Lucini, D ;
Milani, RV ;
Ventura, HO ;
Mehra, MR ;
Messerli, F ;
Pagani, M .
HYPERTENSION, 2000, 35 (06) :1258-1263
[9]   Cardiac transplant experience with cyclosporine [J].
Patel, JK ;
Kobashigawa, JA .
TRANSPLANTATION PROCEEDINGS, 2004, 36 (02) :323S-330S
[10]   LOSS OF NOCTURNAL DECLINE IN BLOOD-PRESSURE AFTER CARDIAC TRANSPLANTATION [J].
REEVES, RA ;
SHAPIRO, AP ;
THOMPSON, ME ;
JOHNSEN, AM .
CIRCULATION, 1986, 73 (03) :401-408