In vitro susceptibilities of non-Enterobacteriaceae isolates from patients with intra-abdominal infections in the Asia-Pacific region from 2003 to 2010: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)

被引：28

作者：

Liu, Yuag-Meng ^{[3
,4
]}

Chen, Yao-Shen ^{[5
,6
,7
]}

Toh, Han-Siong ^{[8
,9
]}

Huang, Chi-Chang ^{[10
]}

Lee, Yu-Lin ^{[4
,11
]}

Ho, Cheng-Mao ^{[3
,12
,13
]}

Lu, Po-Liang ^{[14
]}

Ko, Wen-Chien ^{[3
,4
,16
,17
]}

Chen, Yen-Hsu ^{[14
,15
]}

Wang, Jen-Hsien ^{[12
]}

Tang, Hung-Jen ^{[18
,19
]}

Yu, Kwok-Woon ^{[20
]}

Liu, Yung-Ching ^{[21
,22
]}

Chuang, Yin-Ching ^{[23
,24
]}

Xu, Yingchun ^{[25
]}

Ni, Yuxing ^{[26
]}

Liu, Chun-Eng ^{[4
]}

Hsueh, Po-Ren ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Lab Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, Taiwan

[3] China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan

[4] Changhua Christian Hosp, Dept Internal Med, Div Infect Dis, Changhua, Taiwan

[5] Kaohsiung Vet Gen Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan

[6] Natl Yung Ming Univ, Sch Med, Taipei, Taiwan

[7] Natl Kaohsiung Normal Univ, Grad Inst Environm Educ, Kaohsiung, Taiwan

[8] Chi Mei Med Ctr, Dept Infect Dis, Tainan, Taiwan

[9] Chi Mei Hosp, Dept Intens Care, Chiali, Taiwan

[10] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan 70428, Taiwan

[11] Natl Yang Ming Univ, Grad Inst Clin Med, Taipei 112, Taiwan

[12] China Med Univ Hosp, Dept Internal Med, Div Infect Dis, Taichung, Taiwan

[13] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan

[14] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan

[15] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan

[16] Natl Cheng Kung Univ Hosp, Ctr Infect Control, Tainan 70428, Taiwan

[17] Natl Cheng Kung Univ, Coll Med, Dept Med, Tainan 70101, Taiwan

[18] Chi Mei Med Ctr, Dept Med, Tainan, Taiwan

[19] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan, Taiwan

[20] Taipei Vet Gen Hosp, Dept Internal Med Pathol & Lab Med, Div Infect Dis, Taipei, Taiwan

[21] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan

[22] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei, Taiwan

[23] Chi Mei Med Ctr, Dept Internal Med & Med Res, Tainan, Taiwan

[24] Chi Mei Med Ctr, Dept Internal Med, Tainan, Taiwan

[25] Peking Union Med Coll Hosp, Beijing, Peoples R China

[26] Shanghai Jiao Tong Univ, Coll Med, Shanghai 200030, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2012年 / 40卷

关键词：

Intra-abdominal infections; Antimicrobial susceptibility; Non-Enterobacteriaceae Gram-negative bacilli; Pseudomonas aeruginosa; Acinetobacter baumannii; SMART; INVITRO SUSCEPTIBILITIES; AEROMONAS-HYDROPHILA; WORLDWIDE; STRAINS; BACTEREMIA; PATHOGENS;

D O I：

10.1016/S0924-8579(12)70004-3

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The Study for Monitoring Antimicrobial Resistance Trends (SMART) is an international surveillance study designed to monitor resistance trends among aerobic and facultative Gram-negative bacilli (GNB) isolated from intra-abdominal infections. During 2003-2010, a total of 20710 GNB isolates were collected at medical centers in China, Hong Kong, Korea, New Zealand, and Taiwan. The susceptibility profiles of 2252 isolates of non-Enterobacteriaceae GNB were determined. At least 10 isolates of a given organism were required for that organism to be included in the analysis. Pseudomonas aeruginosa was the leading organism (49.2% of non-Enterobacteriaceae GNB), followed by Acinetobacter baumannii (21.5%), Aeromonas spp. (11.6%), and Stenotrophomonas maltophilia (9.1%). All the other species/genera made up less than 2%. The rates of susceptibility of the four major organisms were examined for two different time periods and according to whether the isolates had been obtained <48 h after hospitalization or >= 48 h after hospital admission. P. aeruginosa, Aeromonas spp., and S. maltophilia showed sustained levels of susceptibility to several antimicrobial agents in the two time periods, whereas A. baumannii exhibited very high rates of resistance to most antimicrobial agents including imipenem. Nosocomial P. aeruginosa and A. baumannii were more resistant than community-acquired pathogens, although this was not the case for Aeromonas spp. and S. maltophilia. Worldwide and regional surveillance is necessary to guide empirical antimicrobial therapy for infections due to non-Enterobacteriaceae GNB. (C) 2012 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：S11 / S17

页数：7

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